P3‐575: Rheumatoid Arthritis, Inflammation Treatment, and Alzheimer's Disease: A Cross‐sectional Descriptive Study Using the Nacc Database

Abstract

generally high (M score¼0.85, SD¼0.21), with 44.9% achieving a perfect score. Mean MAC-Q score was 20.15 (SD¼3.40) when comparing memory to function in their twenties and 17.96 (SD¼2.93) when comparing with others the same age. Both MAC-Q scores were significantly correlated with ADRI total risk (comparing with twenties r S (1154)¼0.10, p¼0.001; comparing with others r S (1154)¼0.11, p<0.001), while only the score for comparing with others the same age was correlated with lifestyle risk (r S (1154)¼0.16, p<0.001). Memory task scores were significantly correlated with total risk (r S (1154)¼-0.11, p<0.001) and lifestyle risk (r S (1154)¼-0.08, p¼0.01), but not with MAC-Q scores. Conclusions:This study found no association between subjective and objective memory. However, greater risk of developing Alzheimer's disease, based on risk factor exposure, was associated with both poorer memory performance and higher subjective memory complaints. Further elucidating relationships between modifiable lifestyle risk factors and memory could have implications for community-based dementia prevention interventions.