P300 as a predictor of recovery from coma

Yingling, CharlesD.; Hosobuchi, Yoshio; Harrington, Margaret

doi:10.1016/0140-6736(90)92372-o

Cited by 47 publications

(13 citation statements)

References 2 publications

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“…However, the data are not systematically convergent. While a great number of studies suggest, as MMN data, that among patients who developed a P300 wave a high proportion of them recovered [17,33,37,38], others do not [31,63]. This variability could be explained by the limited number of patients studied, as well as the limited number of patients evoking a P3 response to deviant tones.…”

Section: The P300 Wavementioning

confidence: 95%

Cognitive Event-Related Potentials in Comatose and Post-Comatose States

2007

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We review the interest of cognitive event-related potentials (ERPs) in comatose, vegetative, or minimally conscious patients. Auditory cognitive ERPs are useful to investigate residual cognitive functions, such as echoic memory (MMN), acoustical and semantic discrimination (P300), and incongruent language detection (N400). While early ERPs (such as the absence of cortical responses on somatosensory-evoked potentials) predict bad outcome, cognitive ERPs (MMN and P300) are indicative of recovery of consciousness. In coma-survivors, cognitive potentials are more frequently obtained when using stimuli that are more ecologic or have an emotional content (such as the patient's own name) than when using classical sine tones.

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Section: The P300 Wavementioning

confidence: 95%

Cognitive Event-Related Potentials in Comatose and Post-Comatose States

2007

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“…In a fluid percussion model of concussion however, the late positive component in the cat (thought to be equivalent to the human P 3 ) was found to be suppressed for some time after the recovery of other neurological functions, including reflexes, motor co-ordination and the orienting response [DeSalles et al, 1987]. None the less, the first reports of late P 3 -like responses in small numbers of unresponsive patients appeared soon after, and its presence was anecdotally associated with a favourable prognosis in both traumatic [Reuter and Linke, 1989;Yingling et al, 1990] and non-traumatic coma [Gott et al, 1991]. A direct comparison between somatosensory EPs and P 3 ERPs showed the short-latency responses to be better predictors of a poor outcome, whilst the long-latency responses were useful predictors of awakening [DeGiorgio et al, 1993].…”

Section: Event-related Potentialsmentioning

confidence: 99%

Coma Outcome Prediction Using Event-Related Potentials: P<sub>3</sub> and Mismatch Negativity

Kane

Butler²,

Simpson

2000

Audiol Neurotol

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The prediction of the outcome from coma is of considerable importance to the patients, their relatives and attendant medical staff, and yet current clinical methods lack sensitivity and specificity. Objective investigations can enhance the accuracy of such predictions and are an important adjuvant when reaching decisions to continue or terminate life support. Of the neurophysiological methods available, electroencephalography and short-latency somatosensory evoked potentials have proved the most useful in the clinical setting. These tests are good predictors of an adverse outcome; however, they tell us only about the ongoing cerebral activity and integrity of the primary somatosensory pathways, respectively. The presence of long-latency event-related potentials has been shown to be a useful predictor of a favourable neurological outcome, and thus their use complements other neurophysiological techniques. Their potential application in clinical practice is reviewed.

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“…(Crit Care Med 2006; 34:1520-1524) KEY WORDS: anoxic coma; somatosensory evoked potentials; event-related potentials; mismatch negativity; prognosis; classification tree than do early sensory evoked potentials. The presence of a P300 component in comatose patients proved to be effective in predicting awakening in short series (11)(12)(13)(14). The absence of P300 does not preclude a good prognosis.…”

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confidence: 99%

Improved prediction of awakening or nonawakening from severe anoxic coma using tree-based classification analysis*

Fischer

Luauté

Némoz

et al. 2006

Critical Care Medicine

168

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There is a need to predict early and accurately awakening or nonawakening in postanoxic comas. Using sensory and cognitive evoked potentials to assess the functional condition of the brain, a prognostic tree for the prediction of awakening/nonawakening in severe anoxic coma has been designed. It is applicable to any patient in this condition and offers the possibility to predict with very high probability awakening when MMN, the earliest component of event-related potentials, is present and nonawakening when MMN and pupillary light reflex are absent or cortical components of somatosensory evoked potentials are abolished.

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P300 as a predictor of recovery from coma

Cited by 47 publications

References 2 publications

Cognitive Event-Related Potentials in Comatose and Post-Comatose States

Cognitive Event-Related Potentials in Comatose and Post-Comatose States

Coma Outcome Prediction Using Event-Related Potentials: P<sub>3</sub> and Mismatch Negativity

Improved prediction of awakening or nonawakening from severe anoxic coma using tree-based classification analysis*

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