P300 changes in major depressive disorders with and without psychotic features

Karaaslan, Fatih; Gönül, Ali Saffet; Oğuz, Aslan; Erdinc, Erdogan; Eşel, Ertuğrul

doi:10.1016/s0165-0327(01)00477-3

Cited by 115 publications

(62 citation statements)

References 23 publications

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“…Generally, quantitative trait association studies (based on phenotypic or endophenotypic subgroups) offer several advantages over case-control studies, one of which is a 4-fold to 8-fold increase in statistical power, thus greatly decreasing the required sample size to achieve sufficient statistical power (Wang et al, 2005;Potkin et al, 2009). Our results of longer P300 latency in MDD patients compared to healthy controls confirm those of previous reports (Bruder et al, 1991;Himani et al, 1999;Karaaslan et al, 2003). Moreover, individuals with the T allele genotype, both in rs6438552 (C/T + T/T) and rs7633279 (A/T + T/T), have a longer P300 latency than those with the C/C or A/A genotype.…”

Section: Discussionsupporting

confidence: 87%

Possible Association of the GSK3β Gene with the Anxiety Symptoms of Major Depressive Disorder and P300 Waveform

Sun

et al. 2012

Genetic Testing and Molecular Biomarkers

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Glycogen synthase kinase-3b (GSK3b) may play an important role in the brain of patients with major depressive disorder (MDD); therefore, we investigated whether the GSK3b gene is involved in the etiology of MDD and whether it affects MDD endophenotypes. Three single-nucleotide polymorphisms (SNPs) (rs6438552, rs7633279, and rs334558) were genotyped in 559 MDD patients and 486 healthy controls. To explore quantitative traits of MDD, we analyzed the association of these SNPs with the factor scores of the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Hamilton Anxiety Rating Scale (HAMA). We also determined the effects of these SNPs on the measurement of the P300 wave. Although no significant association between GSK3b SNPs and MDD was found, some genotypes and haplotypes were associated with anxiety symptoms in MDD. The three SNPs were associated with the HAMA total score and with the HAMD anxiety and somatization factor score ( p < 0.05). Three-locus haplotype analysis showed the C-T-G carriers to have a strong association with the HAMA total score ( p = 0.032). Moreover, the P300 latency and amplitude were also associated with GSK3b genotypes. The individuals with the T allele genotype, both in rs6438552 and rs7633279, have a longer P300 latency than those carrying the C/C ( p = 0.04) and A/A genotype ( p = 0.013). The individuals with the G/G genotype in rs334558 have a lower amplitude than those carrying the A allele genotype ( p = 0.007). Our findings show, for the first time, that GSK3b polymorphisms may play an important role in MDD endophenotypes, especially in anxiety symptoms.

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Section: Discussionsupporting

confidence: 87%

Possible Association of the GSK3β Gene with the Anxiety Symptoms of Major Depressive Disorder and P300 Waveform

Sun

et al. 2012

Genetic Testing and Molecular Biomarkers

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“…Therefore, our negative association of P300 and WCST with the MAOA-uVNTR genotype needs to be replicated in other sample populations. Since previous studies of the MAOA-uVNTR polymorphism have demonstrated a signifi cant association with major depressive disorders [28] , an association between major depressives and signifi cant errors in the WCST [29] and P300 latency prolongation or amplitude decrement [30] , it may be of interest to test the association of the MAOA-uVNTR polymorphism with P300 and WCST in a sample population consisting of patients with major depressive disorders.…”

Section: Discussionmentioning

confidence: 99%

Association Study of a Functional MAOA-uVNTR Gene Polymorphism and Cognitive Function in Healthy Females

Tsai²,

Chen³

et al. 2005

Neuropsychobiology

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Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence quotient (IQ), Wisconsin Card Sorting Test (WCST) and P300 event-related potentials as cognitive assessments for testing the relationship between the polymorphism with a variable number of tandem repeats (VNTR) in the upstream regulatory region (MAOA-uVNTR) and cognition. The results demonstrate that subjects bearing the 4/4-repeat genotype have a significantly higher full IQ than subjects bearing the 3/3-repeat genotype. However, there is no significant association between this MAOA-uVNTR polymorphism and the WCST and P300. Our study shows that the MAOA-uVNTR genetic polymorphism plays a role in the IQ; however, this may be a chance finding as the result was negative after using the Bonferroni adjustment. Therefore, we suggest that our study should be replicated and that the testing method, sex, disease and ethnicity should also be considered in future studies.

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“…Indeed, there is general agreement that a reduction of P3b amplitude is (1) a state marker of depression, i.e., a biological marker that is altered during the disease but that stabilizes after clinical remission (Karaaslan et al, 2003); (2) a trait marker of schizophrenia, i.e., a biological parameter that is changed during and after the disease (Mathalon et al, 2000); (3) a vulnerability marker of alcoholism, i.e., a biological variable that is altered before the emergence of the disease (high-risk children of alcoholic parents) (e.g., Hill et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Is two better than one? A cross-modal oddball paradigm reveals greater sensitivity of the P300 to emotional face-voice associations

Campanella¹,

Bruyer

Froidbise

et al. 2010

Clinical Neurophysiology

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a b s t r a c tObjective: Studies exploring neurophysiological correlates of main psychiatric disorders have commonly used event-related potentials (ERP) during a visual or an auditory oddball task. The main results concern modulations of the P3b amplitude and/or latency. The present study aims to increase the clinical sensitivity of these P3b modulations by using a more ecological oddball design, using synchronized pairs of audio-visual emotional stimuli. Method: Two groups of healthy participants, one composed of controls and the other of students displaying anxious and depressive tendencies completed visual, auditory and audio-visual (cross-modal) oddball tasks, in which they had to detect deviant happy and sad stimuli among neutral ones as quickly as possible. Behavioral performance and P3b ERP data were analyzed. Results: Subjects displaying anxious and depressive tendencies exhibited lower P3b amplitude than the controls, but only in the cross-modal oddball task. Conclusions: Although the two groups of subjects differed in their levels of co-morbid anxiety and depression, unimodal visual and auditory oddball tasks did not allow us to detect this difference by P3b amplitude modulations, but the cross-modal task did. Significance: These results suggest that a cross-modal oddball design should be used in future studies to increase the sensitivity of the P300 amplitude differences between healthy participants and those with clinical symptoms.

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P300 changes in major depressive disorders with and without psychotic features

Cited by 115 publications

References 23 publications

Possible Association of the GSK3β Gene with the Anxiety Symptoms of Major Depressive Disorder and P300 Waveform

Possible Association of the GSK3β Gene with the Anxiety Symptoms of Major Depressive Disorder and P300 Waveform

Association Study of a Functional MAOA-uVNTR Gene Polymorphism and Cognitive Function in Healthy Females

Is two better than one? A cross-modal oddball paradigm reveals greater sensitivity of the P300 to emotional face-voice associations

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