P300 cognitive assessment in patients with first-episode psychosis: a prospective case-control study

Hassan, Wafaa A.; Darweesh, Alaa El-Din M.; Abdel‐Rahman, Adel B.; Ahmad, Hossam Eddin Khalifa; Hassaan, Shehab H; Noaman, Mostafa M.; Fahmy, Iman F. G.

doi:10.1186/s43045-020-00031-2

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…Regarding the P3a latency just one study of those mentioned above highlighted a delayed P3a latency in FES subjects ( 213 ), while all other studies did not identify any alteration in P3a latency, in FEP, FES and HR subjects ( 68 , 163 , 188 , 189 , 196 , 206 , 207 , 209 , 213 – 215 ).…”

Section: Resultsmentioning

confidence: 93%

“…With regard to the P3b latency, two studies reported an increase of this EEG measure in FEP ( 215 , 229 ), while other studies did not detect any abnormalities of this feature in FEP, FES ( 162 , 163 , 165 , 167 , 172 , 213 , 216 – 219 , 221 , 222 , 224 , 227 , 230 – 232 ), and HR subjects ( 68 , 163 , 165 , 168 , 169 , 227 , 228 ), as compared to HCs.…”

Section: Resultsmentioning

confidence: 99%

“…With regard to the P3b latency, two studies reported an increase of this EEG measure in FEP (215,229), while other studies did not detect any abnormalities of this feature in FEP, FES (…”

Section: P3bmentioning

confidence: 92%

“…In FEP and FES subjects, as compared to HCs, different studies have highlighted a decrease of the P3b amplitude (67, 163,164,172,199,210,213,[215][216][217][218][219][220][221][222][223]. One study demonstrated that deficits in P3b, as observed for P3a, were not present at baseline, but emerged when FEP subjects were evaluated at 12-and 24month follow-up visits (166).…”

Section: P3bmentioning

confidence: 99%

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EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

et al. 2021

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Introduction: Electrophysiological (EEG) abnormalities in subjects with schizophrenia have been largely reported. In the last decades, research has shifted to the identification of electrophysiological alterations in the prodromal and early phases of the disorder, focusing on the prediction of clinical and functional outcome. The identification of neuronal aberrations in subjects with a first episode of psychosis (FEP) and in those at ultra high-risk (UHR) or clinical high-risk (CHR) to develop a psychosis is crucial to implement adequate interventions, reduce the rate of transition to psychosis, as well as the risk of irreversible functioning impairment. The aim of the review is to provide an up-to-date synthesis of the electrophysiological findings in the at-risk mental state and early stages of schizophrenia.Methods: A systematic review of English articles using Pubmed, Scopus, and PsychINFO was undertaken in July 2020. Additional studies were identified by hand-search. Electrophysiological studies that included at least one group of FEP or subjects at risk to develop psychosis, compared to healthy controls (HCs), were considered. The heterogeneity of the studies prevented a quantitative synthesis.Results: Out of 319 records screened, 133 studies were included in a final qualitative synthesis. Included studies were mainly carried out using frequency analysis, microstates and event-related potentials. The most common findings included an increase in delta and gamma power, an impairment in sensory gating assessed through P50 and N100 and a reduction of Mismatch Negativity and P300 amplitude in at-risk mental state and early stages of schizophrenia. Progressive changes in some of these electrophysiological measures were associated with transition to psychosis and disease course. Heterogeneous data have been reported for indices evaluating synchrony, connectivity, and evoked-responses in different frequency bands.Conclusions: Multiple EEG-indices were altered during at-risk mental state and early stages of schizophrenia, supporting the hypothesis that cerebral network dysfunctions appear already before the onset of the disorder. Some of these alterations demonstrated association with transition to psychosis or poor functional outcome. However, heterogeneity in subjects' inclusion criteria, clinical measures and electrophysiological methods prevents drawing solid conclusions. Large prospective studies are needed to consolidate findings concerning electrophysiological markers of clinical and functional outcome.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

“…With regard to the P3b latency, two studies reported an increase of this EEG measure in FEP (215,229), while other studies did not detect any abnormalities of this feature in FEP, FES (…”

Section: P3bmentioning

confidence: 92%

Section: P3bmentioning

confidence: 99%

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EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

et al. 2021

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“…Only a pilot study evaluated an evoked potential as a marker of response, and suggested that olanzapine was able to restore the normal features of P300, which has a lower amplitude and a prolonged latency in SZ 121 .…”

Section: Discussionmentioning

confidence: 99%

Pharmaco-EEG of antipsychotic treatment response: a systematic review

De Pieri,

Rochas,

Sabe

et al. 2023

Schizophr

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Response to antipsychotic medications (AP) is subjected to a wide and unpredictable variability and efforts were directed to discover predictive biomarkers to personalize treatment. Electroencephalography abnormalities in subjects with schizophrenia are well established, as well as a pattern of EEG changes induced by APs. The aim of this review is to provide a synthesis of the EEG features that are related to AP efficacy, including both pre-treatment signatures and changes induced by APs during treatment. A systematic review of English articles using PubMed, PsychINFO and the Cochrane database of systematic reviews was undertaken until july 2023. Additional studies were added by hand search. Studies having as an endpoint the relationship between AP-related clinical improvement and electroencephalographic features were included. Heterogeneity prevented a quantitative synthesis. Out of 1232 records screened, 22 studies were included in a final qualitative synthesis. Included studies evaluated resting-state and task-related power spectra, functional connectivity, microstates and epileptic abnormalities. At pre-treatment resting-state EEG, the most relevant predictors of a poor response were a change in theta power compared to healthy control, a high alpha power and connectivity, and diminished beta power. Considering EEG during treatment, an increased theta power, a reduced beta-band activity, an increased alpha activity, a decreased coherence in theta, alpha and beta-band were related to a favorable outcome. EEG is promising as a method to create a predictive biomarker for response to APs; further investigations are warranted to harmonize and generalize the contradictory results of reviewed studies.

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Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents

Zhang,

Yang,

et al. 2023

BMC Psychiatry

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Background Identifying the characteristic neurobiological changes of early psychosis is helpful for early clinical diagnosis. However, previous studies on the brain electrophysiology of children and adolescents with psychosis are rare. Methods This study compared P300 amplitude at multiple electrodes between children and adolescents with first-episode schizophrenia (FES, n = 48), children and adolescents with psychosis risk syndrome (PRS, n = 24), and healthy controls (HC, n = 30). Receiver operating characteristic (ROC) analysis was used to test the ability of P300 amplitude to distinguish FES, PRS and HC individuals. Results The P300 amplitude in the FES group were significantly lower than those in the HC at the Cz, Pz, and Oz electrodes. The P300 amplitude was also significantly lower in the prodromal group than in the HC at the Pz and Oz electrodes. ROC curve analysis showed that at the Pz electrode, the P300 amplitude evoked by the target and standard stimulus showed high sensitivity, specificity, accuracy, and area under the curve value for distinguishing FES from HC individuals. Conclusions This study found early visual P300 deficits in children and adolescents with FES and PRS, with the exclusion of possible influence of medication and chronic medical conditions, suggesting the value of P300 amplitude for the identification of early psychosis.

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P300 cognitive assessment in patients with first-episode psychosis: a prospective case-control study

Cited by 4 publications

References 35 publications

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

Pharmaco-EEG of antipsychotic treatment response: a systematic review

Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents

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