2013
DOI: 10.7150/jca.6582
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p300 Influences Butyrate-Mediated WNT Hyperactivation In Colorectal Cancer Cells

Abstract: Deregulated WNT/catenin pathway, usually resulting from mutations in the adenomatous polyposis coli and beta-catenin genes, drives colorectal tumorigenesis. Dietary fiber has been shown to have a protective role against colorectal cancer (CRC). We have previously demonstrated that the histone deacetylase inhibitor (HDACi) butyrate, a fermentation product of dietary fiber, induces WNT/catenin hyperactivation, which promotes CRC cell apoptosis. Therefore, the ability of butyrate to induce WNT hyperactivation and… Show more

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Cited by 28 publications
(62 citation statements)
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“…In CRC cells, the combined treatment with ICG-001 and butyrate had the most profound suppressive effect on cell growth 26,27. In LT97 cells, we observed (Fig 2…”
Section: Resultsmentioning
confidence: 63%
See 3 more Smart Citations
“…In CRC cells, the combined treatment with ICG-001 and butyrate had the most profound suppressive effect on cell growth 26,27. In LT97 cells, we observed (Fig 2…”
Section: Resultsmentioning
confidence: 63%
“…), and overexpression of p300, but not CBP, upregulated basal and butyrate-induced Wnt activity in CRC cells 27. Therefore, we investigated how CBP/p300 overexpression influences butyrate-mediated Wnt hyperactivation in the LT97 cell line.…”
Section: Resultsmentioning
confidence: 99%
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“…The aberrant activation of the Wnt/β-catenin signaling pathway may increase cell proliferation, which results in the generation of abnormal proteins, thereby accelerating the formation of tumors and carcinogenesis through the expression of downstream target genes (3). A previous study demonstrated that ~90% of cases of colon cancer were associated with excessive activation of this pathway (4). β-catenin is the key molecule of the Wnt/β-catenin signaling pathway (5).…”
Section: Introductionmentioning
confidence: 99%