P311, Friend, or Foe of Tissue Fibrosis?

Stradiot, Leslie; Mannaerts, Inge; Grunsven, Leo A. van

doi:10.3389/fphar.2018.01151

Cited by 14 publications

(7 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors found several muscular structural proteins like the MYH genes MYH1, MYH4, and MYH7 to be downregulated in PCS transcriptomes. The atrophy marker FBXO32 (MAFbx) was significantly overexpressed along with a clearly decreased expression of the yet unknown P311 protein (5), later identified as trans-differentiation regulator NREP which is known to be responsible for cell differentiation (59). The question whether muscle atrophy was cause or effect of impaired muscle maturation remained unanswered.…”

Section: Genetic Characterization Of the Splay Leg Syndromementioning

confidence: 99%

Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

2021

View full text Add to dashboard Cite

The porcine congenital splay leg syndrome (PCS), even though being of transient nature, is still one of the most important causes for piglet losses due to its high incidence and mortality. Although, described decades ago, the pathogenetic mechanism is still elusive. Numerous, mostly descriptive studies characterized the syndrome at clinical, histological and cellular levels but resulted in a highly diverse picture of the syndrome. Broad variability in phenotypical expression and, in case of proper care, the rapid recovery of affected animals complicated a systematical analysis of the underlying pathogenesis. Although, several environmental factors were discussed as potential causes of PCS, most of the evidence points to a hereditary basis of PCS. Nevertheless, only few of the suggested candidate genes from transcriptome and mapping analyses, like F-box protein 32 (FBXO32), could be confirmed so far. Only recently, a genome wide association study revealed genomic regions on five porcine chromosomes and named a number of potential candidate genes, among them homer scaffold protein 1 (HOMER1). This new candidate—a cellular scaffold protein—plays a role in a plethora of cellular signaling cascades, and is not only involved in skeletal muscle differentiation but also critical for muscular function. In this review, we critically elucidate the current state of knowledge in the field and evaluate current achievements in the identification of the pathogenetic mechanism for the syndrome.

show abstract

Section: Genetic Characterization Of the Splay Leg Syndromementioning

confidence: 99%

Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

2021

View full text Add to dashboard Cite

show abstract

“…P311, with the official gene symbol NERP (neuronal regeneration related protein), is a highly conserved 8-kDa intracellular protein. The 68-amino acid sequence of P311 contains a PEST domain (rich in Pro, Glu, Ser, and Thr) in the N-terminus (Stradiot et al, 2018). The domain is also in short-lived proteins such as transcription factors, cytokines and signal molecules, which implies that P311 might belong to one of the protein families (Sommer and Wolf, 2014; Varshavsky, 2014).…”

Section: Introductionmentioning

confidence: 99%

Reconstruction and Functional Annotation of P311 Protein–Protein Interaction Network Reveals Its New Functions

et al. 2019

View full text Add to dashboard Cite

P311 is a highly conserved multifunctional protein. However, it does not belong to any established family of proteins, and its biological function has not been entirely determined. This study aims to reveal the unknown molecular and cellular function of P311. OCG (Overlapping Cluster Generator) is a clustering method used to partition a protein-protein network into overlapping clusters. Multifunctional proteins are at the intersection of relevant clusters. DAVID is an analytic tool used to extract biological meaning from a large protein list. Here we presented OD2 (OCG + DAVID + 2 human PPI datasets), a novel strategy to increase the likelihood to identify biological functions most pertinent to the multifunctional proteins. The principle of OD2 is that OCG prepares the protein lists from multifunctional protein relevant overlapping clusters, for a functional enrichment analysis by DAVID, and the similar functional enrichments, which occurs simultaneously when analyzing two human PPI datasets, are supposed to be the predicted functions. By applying OD2 to two reconstructed human PPI datasets, we supposed the function of the P311 in inflammatory responses, cell proliferation and coagulation, which were confirmed by the following biological experiments. Collectively, our study preliminarily found that P311 could play a role in inflammatory responses, cell proliferation and coagulation. Further studies are required to validate and elucidate the underlying mechanism.

show abstract

“…NREP is thought to stimulate the expression of TGF-β1 by promoting the methylation of the NREP promoter and activating the TGF- β 1 5′/3′ UTR ( Li et al, 2016 ). Recent studies have revealed that NREP promotes renal fibrosis via the TGF-β1 signaling pathway and that the deletion of NREP results in delayed burn wound healing ( Stradiot et al, 2018 ). The process of tumor development has been frequently compared to wound healing owing to several shared molecular and biological processes, including neovascularization, ECM remodeling, and fibrosis ( Chang et al, 2004 ).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of NREP Promotes Migration and Invasion in Gastric Cancer Through Facilitating Epithelial-Mesenchymal Transition

Liu

Zeng

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

P311, Friend, or Foe of Tissue Fibrosis?

Cited by 14 publications

References 112 publications

Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

Reconstruction and Functional Annotation of P311 Protein–Protein Interaction Network Reveals Its New Functions

Overexpression of NREP Promotes Migration and Invasion in Gastric Cancer Through Facilitating Epithelial-Mesenchymal Transition

Contact Info

Product

Resources

About