P32: a sex- and gender-sensitive model for evidence-based precision medicine: from knowledge generation to implementation in the field of kidney transplantation

Sapir‐Pichhadze, Ruth; Oertelt‐Prigione, Sabine

doi:10.1016/j.kint.2022.12.026

Cited by 7 publications

(4 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the use of artificial intelligence and machine-learning approaches to analyze large datasets generated by these technologies could enable the development of predictive models for the early detection and personalized treatment of CKD, it is essential to create sexand gender-sensitive models, as proposed, for example, in the field of kidney transplantation [194]. The development of sex-specific drug dosing and administration protocols, informed by sex-biased expression of pharmacogenes across human tissues, as described in the study by Idda et al, could also improve treatment outcomes in CKD patients [195].…”

Section: Discussionmentioning

confidence: 99%

Role of Sex Hormones in Prevalent Kidney Diseases

Conte

Antonelli

Melica

et al. 2023

IJMS

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is a constantly growing global health burden, with more than 840 million people affected worldwide. CKD presents sex disparities in the pathophysiology of the disease, as well as in the epidemiology, clinical manifestations, and disease progression. Overall, while CKD is more frequent in females, males have a higher risk to progress to end-stage kidney disease. In recent years, numerous studies have highlighted the role of sex hormones in the health and diseases of several organs, including the kidney. In this review, we present a clinical overview of the sex-differences in CKD and a selection of prominent kidney diseases causing CKD: lupus nephritis, diabetic kidney disease, IgA nephropathy, and autosomal dominant polycystic kidney disease. We report clinical and experimental findings on the role of sex hormones in the development of the disease and its progression to end-stage kidney disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of Sex Hormones in Prevalent Kidney Diseases

Conte

Antonelli

Melica

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Herein, contextualisation should be prioritised over broad generalisation, as these considerations steer away from a one-size-fits-all paradigm and towards precision medicine. 3 , 55 , 56 Recognising these nuanced interactions will ensure more tailored and effective health interventions.…”

Section: Discussionmentioning

confidence: 99%

Gender-aware Parkinson’s care: a design-based study of patient perspectives on gender norms and gender-sensitive care

Göttgens,

Modderkolk,

Vermuë

et al. 2023

eClinicalMedicine

Self Cite

View full text Add to dashboard Cite

“…This involves considering factors such as socioeconomic status, geographic location, and cultural diversity to prevent the exacerbation of existing healthcare inequities . The regulatory landscape in precision medicine is evolving to keep pace with scientific advancements. , Regulatory agencies, such as the U.S. Food and Drug Administration (FDA), are faced with the challenge of expeditiously reviewing and approving new targeted therapies and diagnostic tests. Balancing the need for swift access to innovative treatments with the requirement of rigorous safety and efficacy assessments is a significant regulatory challenge.…”

Section: Challenges and Considerations In Precision Medicine Implemen...mentioning

confidence: 99%

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted therapy and immunotherapy selection. Biomarkers such as microsatellite instability (MSI) and DNA mismatch repair deficiency (dMMR) guide treatment decisions, opening avenues for immunotherapy. Emerging technologies such as liquid biopsies, artificial intelligence, and machine learning promise to revolutionize early detection, monitoring, and treatment selection in precision medicine. Despite these advancements, ethical and regulatory challenges, including equitable access and data privacy, emphasize the importance of responsible implementation. The dynamic nature of colorectal cancer, with its tumor heterogeneity and clonal evolution, underscores the necessity for adaptive and personalized treatment strategies. The future of precision medicine in colorectal cancer lies in its potential to enhance patient care, clinical outcomes, and our understanding of this intricate disease, marked by ongoing evolution in the field. The current reviews focus on providing in-depth knowledge on the various and diverse approaches utilized for precision medicine against colorectal cancer, at both molecular and biochemical levels.

show abstract

P32: a sex- and gender-sensitive model for evidence-based precision medicine: from knowledge generation to implementation in the field of kidney transplantation

Cited by 7 publications

References 71 publications

Role of Sex Hormones in Prevalent Kidney Diseases

Role of Sex Hormones in Prevalent Kidney Diseases

Gender-aware Parkinson’s care: a design-based study of patient perspectives on gender norms and gender-sensitive care

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Contact Info

Product

Resources

About