P32 Bullous Pemphigoid in Childhood and Infancy. A case of a 4-months old post vaccination

Abstract

The first case of bullous pemphigoid was reported in 1970, however, this remains a mystery. Two peaks of incidences of BP in childhood have been reported in the first year of life (infantile BP) and around the age of 8 years old. Bullous pemphigoid is characterized by circulating autoantibodies that attack basal skin membrane antigens. Increasing numbers of cases have recently increased the suspicion around the link to immunization. We present the case of a 4-month-old male born at full term with no family history of skin diseases and progressive blistering disease manifesting as a papulovesicular eruption on the face, acral sites, and the trunk while sparing the back, who also recently received a 12-week vaccination. He was treated with Steroids, Intravenous immunoglobulin, and Erythromycin. However, management has been challenging due to limited evidence regarding treatment. He responded well with no relapse. Resources: Medline, Embase, and Google