P335 Thiopurine nonadherence is more common in adolescents than adults with IBD, is associated with psychological distress and impacts on the management and prognosis

Review article: strategies for the management of chronic unremitting ulcerative colitis

“…Adherence rates for first‐line prescribed 5ASA therapy in patients with UC have been found to be as low as 60–70% . Non‐adherence rates to prescribed thiopurine treatment, objectively defined using thiopurine metabolite levels, have been shown to be higher in adolescent patients than adult patients (20% vs. 12%, P < 0.05), and appear to be associated with anxiety and depression . Non‐adherence is associated with an increased risk of relapse and a reduced quality of life .…”