P34 Lipid-Lowering Effect of Methanolic Extract of Vernonia Amygdalina Leaves in Rats Fed on High Cholesterol Diet

Adaramoye, Oluwatosin A.; Achem, J.; Akintayo, O.; Fafunso, M.

doi:10.1016/s1567-5688(10)70101-x

Cited by 6 publications

(5 citation statements)

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“…Luteolin is reported as a strong antioxidant compound (32,76). Studies have revealed that the aqueous and ethanol extracts of the plants' leaves, at about 200 mg/kg dosage, exhibit antioxidant properties, including scavenging free radicals, inhibiting the bleaching of β-carotene, and ameliorating serum malondialdehyde in both in vitro and rat models (38,(77)(78)(79)(80)(81).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Phytochemical, Pharmacological, Phyto-cosmeceutical, Toxicity, and In silico Toxicological Evaluations of Vernonia amygdalina Delile – A Review

Atolani,

Banerjee,

Ayenı

et al. 2024

Journal of the Turkish Chemical Society Section A: Chemistry

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Vernonia amygdalina Delile, which is in the Asteraceae family, is used as food and medicine all over the world, especially in Africa and Asia. This review reports the phytochemical, ethnopharmacological, phyto-cosmeceutical, and toxicological potentials of the plant. Recent scientific exploration of the plant has mainly focused on both its nutritional potential and ethnopharmacological properties. The antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, hematological, anti-plasmodial, antimicrobial, anticancer, neurological, cosmeceutical, and other pharmacological values of V. amygdalina continue to be extensively explored. Many empirical studies of the therapeutic potential of the plant have attributed the ethnomedicinal properties of the plant to its phytochemical constituents, which include glycosides, saponins, tannins, terpenoids, etc. Compounds obtained from the leaves, root, stem, and flowers, which include vemoniosides, vernoamyosides, vernoniamyosides, vernoniosides, vernolide, vernodalol, vernodalin, vernomenin, vernomygdin, vernodalinol, epivernodalol, vernolepin, coumarins, luteolin, edotides, etc. have been identified as bioactive constituents responsible for numerous pharmacological activities of the plant. In addition, the toxicological evaluation of the plant revealed that it is safe for consumption at relatively high concentrations.

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Section: Antioxidant Activitymentioning

confidence: 99%

Phytochemical, Pharmacological, Phyto-cosmeceutical, Toxicity, and In silico Toxicological Evaluations of Vernonia amygdalina Delile – A Review

Atolani,

Banerjee,

Ayenı

et al. 2024

Journal of the Turkish Chemical Society Section A: Chemistry

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“…There are reports 14,15 on the incorporation of the leaves into diet by weight which have documented the lipid modulating effect in normal adult rats. The anti-hyperlipidemic activity of extracts from the plant extract has also been demonstrated 16 .…”

Section: Introductionmentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:The challenges of free radicals and tumour promoting agents are on the increase and this informed investigation of the antioxidant property and anticancer potential of Vernonia amygdalina, a most common medicinal vegetable in Nigeria. The leaf of Vernonia amygdalina was extracted in methanol and partitioned into hexane, ethyl acetate and aqueous layers successively. Activity guided fractionation further subjected the active ethyl acetate fraction to vacuum liquid chromatography (VLC). The antioxidant activity of the extracts was measured by the DPPH radical scavenging assay. The anticancer potential of the plant extracts was assessed by the DNA nicking assay and apoptosis induction assay. The sensitivity of the mitochondrial membrane transition pore was determined by studying the rate of change in absorbance at 540 nm under energized and de-energized conditions using Spectrum Lab UV-visible spectrophotometer. The antioxidant activity of the extracts varied considerably with respect to IC 50 values. The results proved that V. amygdalina extracts had significant reduction in the formation of nicked DNA but demonstrated increased native form of DNA. The column fractions induced apoptosis in isolated rat hepatic mitochondria by increasing the mitochondrial membrane permeability pore opening. The findings showed that V. amygdalina have constituents that possess promising antioxidant and anticancer properties.

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“…Therefore, it is expected that a decrease in LDL will trigger a rise in HDL-C in the blood. In addition, VA leaves are thought to have an antiatherogenic role by inhibiting lipid oxidation, which also increases HDL-C 11 .…”

Section: Introductionmentioning

confidence: 99%

The Increase of HDL-C Levels using Ethanol Extract of Vernonia amygdalina Leaves in Wistar Rats Models of Metabolic Syndrome

Pakha,

Nurwati,

Sunggoro

et al. 2024

SMedJour

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Introduction: Metabolic syndrome (MetS) is a cluster of metabolic factors, including low high-density lipoprotein cholesterol (HDL-C) levels. Vernonia amygdalina (VA) leaves have been documented for their anti-cholesterol properties. The purpose of this study to evaluate ethanol extract of VA leaves in rising HDL-C levels in the MetS model.Methods: An experimental study using pre-and post-test design was conducted using 30 male Wistar rats divided into five groups randomly. KN group served as the control group. KP group was the MetS model without ethanol extract administration. Meanwhile, P1, P2, and P3 were MetS models and were administered ethanol extract of VA leaves administration (50mg/kg, 100mg/kg, and 150 mg/kg) for 28 days. The data were analysed using paired t-test and one-way ANOVA (α=0,05).Results: This study discovered that administering the extract in P1, P2, and P3 significantly improved HDL levels. Furthermore, increasing the dose resulted in significantly greater HDL levels. VA leaves contain phytochemicals that have impacts on cholesterol levels in the blood. Flavonoids and tannin inhibit ester cholesterol formation. Terpenoid and flavonoid hinder HMG-CoA. Saponin contributes to free cholesterol transporter, reducing oxidative stress and increasing LDL receptors. Lastly, vitamin C raises catabolism levels and clearance LDL.Conclusion: There are increases in HDL levels in the MetS model group receiving ethanol extract VA leaves.

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P34 Lipid-Lowering Effect of Methanolic Extract of Vernonia Amygdalina Leaves in Rats Fed on High Cholesterol Diet

Cited by 6 publications

References 0 publications

Phytochemical, Pharmacological, Phyto-cosmeceutical, Toxicity, and In silico Toxicological Evaluations of Vernonia amygdalina Delile – A Review

Phytochemical, Pharmacological, Phyto-cosmeceutical, Toxicity, and In silico Toxicological Evaluations of Vernonia amygdalina Delile – A Review

Untitled

The Increase of HDL-C Levels using Ethanol Extract of Vernonia amygdalina Leaves in Wistar Rats Models of Metabolic Syndrome

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