P350 Effects of Atopic Disease on Disease Severity in Covid-19

Timberlake, Dylan; Narayanan, Divya; Ogbogu, Princess U.; Raveendran, Reena; Prince, Bridgette; Scherzer, Rebecca; Porter, K. R. D.; Grayson, Mitchell H.

doi:10.1016/j.anai.2020.08.147

Cited by 1 publication

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“…The presence of AD was not associated with any of the following secondary end points: supplemental oxygen (P = 0.360), intubation rate (P = 0.920), and mortality rate (P = 0.190). 16 It is noteworthy that this study is hindered by the small sample size and the short follow-up period (2 months). The burden of COVID-19 in large cohorts of patients with AD is yet to be outlined.…”

Section: Discussionmentioning

confidence: 96%

“…26 Atopic dermatitis has been found to associate with other aberrancies of both the innate and adaptive immune pathways, which may predispose to cutaneous and extracutaneous infections. 27,28 A retrospective study encompassing 275 inpatient subjects with COVID-19 infection, Timberlake et al 16 investigated whether a history of atopic diseases affects prognostic outcomes of COVID-19. The study denoted that the frequency of intensive care unit admission was comparable in patients with and without atopic comorbidities (43.0% vs 44.7%, respectively; P = 0.840).…”

Section: Discussionmentioning

confidence: 99%

“…16 In a study following 275 patients with COVID-19, atopic comorbidities were not associated with an increased risk of hospitalization. 16 However, the burden of COVID-19 among patients with AD is poorly understood, and determinants of worse prognostic outcomes in this group remain to be delineated. The aim of the current study was to characterize a large cohort of adult patients with AD who tested positive for COVID-19.…”

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confidence: 96%

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confidence: 99%

“…Based on data arising from the swine flu pandemic in 2009, atopic diseases were found to confer protection from severe disease in hospitalized patients 16 . In a study following 275 patients with COVID-19, atopic comorbidities were not associated with an increased risk of hospitalization 16 . However, the burden of COVID-19 among patients with AD is poorly understood, and determinants of worse prognostic outcomes in this group remain to be delineated.…”

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confidence: 99%

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The Burden of Coronavirus Disease 2019 and Its Complications in Patients With Atopic Dermatitis—A Nested Case-Control Study

et al. 2021

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Background: The burden of coronavirus disease 2019 (COVID-19) among patients with atopic dermatitis (AD) is poorly understood.Objectives: The aims of the study were to characterize a large cohort of COVID-19-positive adult patients with AD and to identify predictors of COVID-19-associated hospitalization and mortality.Methods: A population-based nested case-control study was performed. Multivariable logistic regression was used to evaluate odds ratios and 95% confidence intervals of predictors for COVID-19-associated hospitalization and mortality.Results: Of 78,073 adult patients with AD, 3618 (4.6%) tested positive for COVID-19. Subclinical COVID-19 infection occurred in 3368 (93.1%) of COVID-19-positive patients, whereas 123 (3.4%), 46 (1.3%), 55 (1.5%), and 26 (0.7%) patients developed a mild, moderate, severe, and critical disease, respectively. Altogether, 250 patients (6.0%) were hospitalized, and 40 patients (1.1%) died because of COVID-19 complications. Coronavirus disease 2019-associated hospitalization was independently associated with the intake of extended courses of systemic corticosteroids (adjusted odds ratio, 1.96; 95% confidence interval, 1.23-3.14; P = 0.005). None of AD-related variables independently predicted COVID-19-associated mortality. The presence of comorbid metabolic syndrome, chronic obstructive pulmonary disease, chronic renal failure, and depression projected both COVID-19-associated hospitalization and mortality.Conclusions: Prolonged systemic corticosteroids during the pandemic are associated with increased odds of COVID-19associated hospitalization and should be avoided in patients with AD.

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Section: Discussionmentioning

confidence: 96%