P36. Antistress and angioprotective influence of nitric oxide and nitrite in epilepsy-prone rats of Krushinsky–Molodkina strain

The Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65 years

“…At the same time, the protective effect of hypoxic "training" disappeared after the administration of NOsynthase inhibitor (L-NNA). The study demonstrated that nitric oxide (NO) participates in adaptive reactions of cerebral hemodynamics, which is linked with the significant increase of cerebral blood flow [70].…”

“…This problem is very important both for practical goals [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86] and for theoretical issues, as well [68,76,77]. The examples of such effects are numerous, but in spite of this, the respective mechanisms stay mainly unexplored.…”

Audiogenic Seizures - Biological Phenomenon and Experimental Model of Human Epilepsies

“…At the same time the protective effect of hypoxic "training" disappeared after the administration of NO-synthase inhibitor (L-NNA). The study demonstrated that nitric oxide (NO) participates in adaptive reactions of cerebral hemodynamics linked with the significant increase of cerebral blood flow (Fadiukova et al, 2005).…”