P376 Vincristine teratologic effect in newborn mice

Hejazi, S

doi:10.1016/s0020-7292(09)61867-1

Cited by 1 publication

(2 citation statements)

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“…Forty females at (12)(13)(14) weeks of age were placed in the evening with mature males (2 female: 1 male). Copulation was checked by the presence of vaginal plug next morning or by the finding of sperm in the vaginal smear when vaginal plugs were less conspicuous than usual.…”

Section: E-teratogenicity Investigationmentioning

confidence: 99%

“…Twenty pregnant females were administered by a single subcutaneously injection at 0.767gm/kg body weight of C roseus aqueous extract on the day 10 through day 16 of gestation period. A further twenty pregnant mice were used as control group which received 1ml of PBS/day subcutaneously (13). All animals were observed daily throughout pregnancy, and then all dams were allowed to deliver naturally.…”

Section: E-teratogenicity Investigationmentioning

confidence: 99%

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An Investigation of the Cytotoxic, Cytogenetic and Teratogenic Potentials of Catharanthusroseus

2016

IJSR

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The results revealed that the plant extract showed a significant induction of sperm abnormalities at the three concentrations used comparing with the untreated animals. The administration of a single injection of 0.767gm/kg of C. roseus extract to twenty pregnant females mice on the day 10 through 16 of gestation period did not show any apparent malformations. However, compared with the control population of the pup's number, body length, and head length was significantly reduced within the first day of life. Overall, those finding indicate that Catharanthus roseus aqueous extract can induce significant mitotic inhibition, slight chromosome aberrations and micronuclei frequencies and it can bring about significant percentage of abnormal spermatozoa, besides its ability to cross placental barrier causing some growth retardation; rather than teratogenic effects.

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Section: E-teratogenicity Investigationmentioning

confidence: 99%

Section: E-teratogenicity Investigationmentioning

confidence: 99%