2010
DOI: 10.1016/j.canlet.2010.02.017
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p38 MAPK and NF-κB pathways are involved in naphtho[1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells

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Cited by 53 publications
(36 citation statements)
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“…Nowadays melatonin, the main product of the pineal gland, has attracted increasing attention because of its protective role in several pathophysiological situations, including different cancer types, where it exerts oncostatic effects (Hill and Blask, 1988; Farriol et al , 2000; Futagami et al , 2001; Cini et al , 2005; Garcia-Santos et al , 2006; Garcia-Navarro et al , 2007; Mauriz et al , 2007; Cabrera et al , 2010; Chiu et al , 2010; Gonzalez et al , 2010; Carbajo-Pescador et al , 2011, 2013). Our group has shown the melatonin oncostatic activity in HepG2 liver tumour cells, highlighting its pro-apoptotic properties through upregulation of cell death-related processes (Martin-Renedo et al , 2008; Carbajo-Pescador et al , 2009, 2011, 2013).…”
mentioning
confidence: 99%
“…Nowadays melatonin, the main product of the pineal gland, has attracted increasing attention because of its protective role in several pathophysiological situations, including different cancer types, where it exerts oncostatic effects (Hill and Blask, 1988; Farriol et al , 2000; Futagami et al , 2001; Cini et al , 2005; Garcia-Santos et al , 2006; Garcia-Navarro et al , 2007; Mauriz et al , 2007; Cabrera et al , 2010; Chiu et al , 2010; Gonzalez et al , 2010; Carbajo-Pescador et al , 2011, 2013). Our group has shown the melatonin oncostatic activity in HepG2 liver tumour cells, highlighting its pro-apoptotic properties through upregulation of cell death-related processes (Martin-Renedo et al , 2008; Carbajo-Pescador et al , 2009, 2011, 2013).…”
mentioning
confidence: 99%
“…Western Blot assay was conducted according to a previously published article [46]. In brief, cells were harvested and lysed.…”
Section: Methodsmentioning
confidence: 99%
“…The assessment has been described previously [46]. In brief, seeded cells were pre-treated with MAPK inhibitors for 2 h respectively.…”
Section: Methodsmentioning
confidence: 99%
“…Western blotting assay was described previously with minor modifications [28]. In brief, 20  μ g protein was resolved by 10% SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and then electrotransferred to a polyvinylidene fluoride (PVDF) membrane.…”
Section: Methodsmentioning
confidence: 99%