p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart?

Engelbrecht, Anna‐Mart; Esterhuyse, Johan; Toit, Eugene F. Du; Lochner, Amanda; Rooyen, Jacques Van

doi:10.1016/j.jnutbio.2005.05.001

Cited by 23 publications

(29 citation statements)

References 35 publications

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“…Supplementation of diet with omega-3 polyunsaturated fatty acids (omega-3 PUFA) purported to reduce the risk of heart failure leads to increased AKT expression, although activity was maintained at constant levels (169). Dietary supplementation with red palm oil improves recovery from ischemia-reperfusion injury in rats associated with increased AKT phosphorylation (179). …”

Section: Akt In the Myocardial Contextmentioning

confidence: 99%

Myocardial AKT: The Omnipresent Nexus

Sussman

Völkers

Fischer

et al. 2011

Physiological Reviews

199

173

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One of the greatest examples of integrated signal transduction is revealed by examination of effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of multiple afferent and efferent signals, AKT exemplifies a molecular sensing node that coordinates dynamic responses of the cell in literally every aspect of biological responses. The balanced and nuanced nature of homeostatic signaling is particularly essential within the myocardial context, where regulation of survival, energy production, contractility, and response to pathological stress all flow through the nexus of AKT activation or repression. Equally important, the loss of regulated AKT activity is primarily the cause or consequence of pathological conditions leading to remodeling of the heart and eventual decompensation. This review presents an overview compendium of the complex world of myocardial AKT biology gleaned from more than a decade of research. Summarization of the widespread influence that AKT exerts upon myocardial responses leaves no doubt that the participation of AKT in molecular signaling will need to be reckoned with as a seemingly omnipresent regulator of myocardial molecular biological responses.

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Section: Akt In the Myocardial Contextmentioning

confidence: 99%

Myocardial AKT: The Omnipresent Nexus

Sussman

Völkers

Fischer

et al. 2011

Physiological Reviews

199

173

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“…20,26,28,29 To determine a potential mechanism for cardiac functional improvement, Engelbrecht et al 30 investigated the regulation of MAPK and PKB/Akt in the presence and absence of dietary RPO supplementation in ischaemia/reperfusion-induced injury. The investigators used Wistar rats and fed them either a standard control diet or a control diet supplemented with RPO for six weeks.…”

Section: Effects On the Heartmentioning

confidence: 99%

Red palm oil: nutritional, physiological and therapeutic roles in improving human wellbeing and quality of life

Oguntibeju

Esterhuyse

Truter

2009

British Journal of Biomedical Science

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The link between dietary fats and cardiovascular disease has created a growing interest in dietary red palm oil research. Also, the link between nutrition and health, oxidative stress and the severity or progression of disease has stimulated further interest in the potential role of red palm oil (a natural antioxidant product) to improve oxidative status by reducing oxidative stress in patients with cardiovascular disease, cancer and other chronic diseases. In spite of its level of saturated fatty acid content (50%), red palm oil has not been found to promote atherosclerosis and/or arterial thrombosis. This is probably due to the ratio of its saturated fatty acid to unsaturated fatty acid content and its high concentration of antioxidants such as beta-carotene, tocotrienols, tocopherols and vitamin E. It has also been reported that the consumption of red palm oil reduces the level of endogenous cholesterol, and this seems to be due to the presence of the tocotrienols and the peculiar isomeric position of its fatty acids. The benefits of red palm oil to health include a reduction in the risk of arterial thrombosis and/or atherosclerosis, inhibition of endogenous cholesterol biosynthesis, platelet aggregation, a reduction in oxidative stress and a reduction in blood pressure. It has also been shown that dietary red palm oil, taken in moderation in animals and humans, promotes the efficient utilisation of nutrients, activates hepatic drug metabolising enzymes, facilitates the haemoglobinisation of red blood cells and improves immune function. This review provides a comprehensive overview of the nutritional, physiological and biochemical roles of red palm oil in improving wellbeing and quality of life.

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“…The question may be posed whether the observed protection was offered against reversible stunning or infarction. However, studies using a similar model where function was the focus have been published (Engelbrecht et al, 2006, Du Toit et al, 2001) [38, 39]. Myocardial stunning has been established as a manifestation of reperfusion injury [40, 41].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Akt Attenuates RPO-Induced Cardioprotection

Katengua-Thamahane

Engelbrecht

Esterhuyse

et al. 2012

Cardiology Research and Practice

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Previous studies have shown that red palm oil (RPO) supplementation protected rat hearts against ischaemia-reperfusion injury. Evidence from these studies suggested that Akt may be partly responsible for the observed protection. The aim of the current study was therefore to prove or refute the involvement of Akt in the RPO-induced cardioprotection by administration of a specific Akt inhibitor (A6730). Male Wistar rats were randomly divided into 2 groups: a control group receiving standard rat chow and an experimental group receiving standard rat chow plus 2 mL RPO for six weeks. Hearts were excised and mounted on the Langendorff perfusion system. Functional recovery was documented. A different set of hearts were freeze-clamped to assess total and phosphorylation status of Akt. Another set of hearts were subjected to the same perfusion conditions with addition of A6730. Hearts from this protocol were freeze-clamped and assessed for total and phospho-Akt. RPO improved functional recovery which was associated with increased phosphorylation of Akt on Ser473 and Thr308 residues. Blockade of Akt phosphorylation caused poor functional recovery. For the first time, these results prove that Akt plays an important role in the RPO-induced cardioprotection.

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p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart?

Cited by 23 publications

References 35 publications

Myocardial AKT: The Omnipresent Nexus

Myocardial AKT: The Omnipresent Nexus

Red palm oil: nutritional, physiological and therapeutic roles in improving human wellbeing and quality of life

Inhibition of Akt Attenuates RPO-Induced Cardioprotection

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