2016
DOI: 10.1080/2162402x.2016.1264564
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p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells

Abstract: The mechanisms that regulate the expression of the NKG2D and DNAM-1 activating ligands are only partially known, but it is now widely established that their expression is finely regulated at transcriptional, post-transcriptional and post-translational level, and involve numerous stress pathways depending on the type of ligand, stressor, and cell context.We show that treatment of Multiple Myeloma (MM) cells with sub-lethal doses of Vincristine (VCR), an anticancer drug that inhibits the assembly of microtubules… Show more

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Cited by 32 publications
(26 citation statements)
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“…MM bone marrow aspirates were cleared from red cells in a buffer containing 1.5 mol/L NH 4 Cl, 100 mmol/L NaHCO 3 and 10 mmol/L ethylenediaminetetraacetic acid (EDTA). Bone marrow-derived mononuclear cells were maintained at 37 °C and 5% CO 2 in complete medium supplemented with 20 ng/mL human recombinant IL-3 (Pepro-Tech, 200–03) and 2 ng/mL human recombinant IL-6 (Pepro-Tech, 200–06), as previously described 55 .…”
Section: Methodsmentioning
confidence: 99%
“…MM bone marrow aspirates were cleared from red cells in a buffer containing 1.5 mol/L NH 4 Cl, 100 mmol/L NaHCO 3 and 10 mmol/L ethylenediaminetetraacetic acid (EDTA). Bone marrow-derived mononuclear cells were maintained at 37 °C and 5% CO 2 in complete medium supplemented with 20 ng/mL human recombinant IL-3 (Pepro-Tech, 200–03) and 2 ng/mL human recombinant IL-6 (Pepro-Tech, 200–06), as previously described 55 .…”
Section: Methodsmentioning
confidence: 99%
“…Regarding drugs that disrupt the microtubule assembly, sub-lethal doses of Vincristine can activate p38 MAPK and regulate NKG2DL expression both at transcriptional and posttranscriptional level in MM cells ( 50 ). Moreover, Cytochalasin D, nocodazole, and docetaxel can enhance NKG2D, DNAM-1, and NKp30 ligands on tumor cell surface, with MICA upregulation being dependent on both DNA damage and endoplasmic reticulum (ER) stress response ( 51 ).…”
Section: Regulation Of Nk Cell-activating and -Inhibitory Ligand Exprmentioning
confidence: 99%
“…In addition, the heat shock pathway, the oxidative stress pathway and the endoplasmic reticulum stress response may act together with the DDR pathway to ensure NKG2DL expression in unhealthy cells [ 3 , 4 ]. Anti-cancer therapeutic interventions may also improve the efficacy of NK cell immune-surveillance affecting NKG2DL expression in tumor cells, as demonstrated by several evidences including those obtained on the hematological cancer Multiple Myeloma (MM) [ 28 , 29 , 30 , 31 , 32 ].…”
Section: Nkg2d/nkg2d Ligand Axis In the Recognition Of Damaged Celmentioning
confidence: 99%