P4‐020: The first third‐generation Alzheimer mouse, PLB1: EEG and activity behaviour

FDG–PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease

“…and qEEG changes at rest in APP/PS1-overexpressing mice (Table 1) using wireless microchip technologies and observed elevated wakefulness pre-plaque, and a genotypeand age-dependent decline in low and an increase in highfrequency spectral EEG power [39]. Other plaque-bearing mice (Tg2576) also presented with reduced REM sleep at 6 and 12 months, but sleep fragmentation and AD-like shifts in spectral power (recorded above the parietal cortex) have so far only been observed in a pilot study conducted in our PLB1 Triple mice [40][41][42] (see Figure 2 and Table 1), and showed congruency with FDG hypometabolism maps ( Figure 1). Intriguing is the vast difference in experimental acquisition time (minutes in PET, 24 h in qEEG), lending compelling support to the notion that PLB1 Triple mice express robust translational biomarkers accessible to both metabolic and physiological imaging.…”