P4.16 Effects of different exercises on hemodynamic responses in Duchenne muscular dystrophy

Alemdaroğlu, I.; Karaduman, Ayşe; Yýlmaz, O.; Topaloǧlu, Haluk

doi:10.1016/j.nmd.2010.07.212

Cited by 1 publication

(1 citation statement)

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“…Twenty-four studies were excluded because: i) they included patients with muscular dystrophy in a wider group of patients with neuromuscular diseases (n = 6) (7–12); ii) used interventions combined with other than exercise interventions (e.g. medication) (n = 3) [20], [21], [22], had no control group (n = 5) [23], [24], [25], [26], [27], had a healthy control group (n = 7) [28], [29], [30], [31], [32], [33] or other interventions as control group (n = 1) [34]. Results from two trials were reported in more than one publications [7], [35].…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Muscle Exercise in Patients with Muscular Dystrophy: A Systematic Review Showing a Missed Opportunity to Improve Outcomes

Gianola

Pecoraro

Lambiase³

et al. 2013

PLoS ONE

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BackgroundAlthough muscular dystrophy causes muscle weakness and muscle loss, the role of exercise in the management of this disease remains controversial.ObjectiveThe purpose of this systematic review is to evaluate the role of exercise interventions on muscle strength in patients with muscular dystrophy.MethodsWe performed systematic electronic searches in Medline, Embase, Web of Science, Scopus and Pedro as well as a list of reference literature. We included trials assessing muscle exercise in patients with muscular dystrophy. Two reviewers independently abstracted data and appraised risk of bias.ResultsWe identified five small (two controlled and three randomized clinical) trials comprising 242 patients and two ongoing randomized controlled trials. We were able to perform two meta-analyses. We found an absence of evidence for a difference in muscle strength (MD 4.18, 95% CIs - 2.03 to 10.39; p = 0.91) and in endurance (MD −0.53, 95% CIs –1.11 to 0.05; p = 0.26). In both, the direction of effects favored muscle exercise.ConclusionsThe first included trial about the efficacy of muscular exercise was published in 1978. Even though some benefits of muscle exercise were consistently reported across studies, the benefits might be due to the small size of studies and other biases. Detrimental effects are still possible. After several decades of research, doctors cannot give advice and patients are, thus, denied basic information. A multi-center randomized trial investigating the strength of muscles, fatigue, and functional limitations is needed.

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