P4‐356: Decreased activation along the dorsal visual pathway after three month treatment with galantamine in mild Alzheimer's disease: An fMRI study

Bokde, Arun L.W.; Karmann, Michaela; Teipel, Stefan J.; Born, Christine; Lieb, Martin; Reiser, Maximilian; Möller, H.-J.; Hampel, Harald

doi:10.1016/j.jalz.2008.05.2427

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus we believe that the slow RT and greater DMN deactivation we see are unlikely to be due to dopaminergic medication. Cholinergic drugs have been reported to improve attentional function (Bentley et al, ; Broks et al, ; McKeith et al, ), largely by modulating frontoparietal networks (Bentley et al, ; Bokde et al, ; Risacher et al, ). Most of the LBD patients were taking cholinesterase inhibitor medication, which has been shown to result in faster RT in Parkinson's disease (Rowan et al, 2007), so may have reduced response latencies in subjects, although we did not see any differences in those patients taking such medication compared to those not on these agents.…”

Section: Discussionmentioning

confidence: 99%

Long reaction times are associated with delayed brain activity in lewy body dementia

Firbank

O’Brien

2017

Human Brain Mapping

View full text Add to dashboard Cite

A significant symptom of Lewy body dementia (LBD) is slow cognitive processing or bradyphrenia. In a previous fMRI task‐based study, we found slower responses in LBD, accompanied by greater deactivation in the default mode network. In this study, we investigated the timing and magnitude of the activations and deactivations with respect to reaction time to determine whether the slower responses in LBD were associated with delayed neuronal activity. Using fMRI, we examined the magnitude and latency of activations and deactivations during an event‐related attention task in 32 patients with LBD and 23 healthy controls using predefined regions of interest. Default mode network deactivations did not significantly differ in their timing between groups or task conditions, while the task‐related activations in the parietal, occipital, frontal, and motor cortex were all significantly later in the LBD group. Repeating the analysis with reaction time as a parametric modulator of activation magnitude produced similar findings, with the reaction time modulator being significant in a number of regions including the default mode network, suggesting that the increased deactivation in LBD is partly explained by slower task completion. Our data suggest that the default mode network deactivation is initiated at the start of the task, and remains deactivated until its end, with the increased magnitude of deactivation in LBD reflecting the more prolonged cognitive processing in these patients. These data add substantially to our understanding of the neural origins of bradyphrenia, which will be essential for determining optimum therapeutic strategies for cognitive impairment in LBD. Hum Brain Mapp 39:633–643, 2018. © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Long reaction times are associated with delayed brain activity in lewy body dementia

Firbank

O’Brien

2017

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Another limitation was the effect of concurrent psychotropic medication. Cholinergic drugs are reported to improve attentional function in controls and dementia [Bentley et al, ; Broks et al, ; McKeith et al, ], mostly by modulating frontoparietal networks [Bentley et al, ; Bokde et al, ; Risacher et al, ]. All but five patients were on cholinesterase inhibitors, thus an effect of these cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Neural correlates of attention‐executive dysfunction in lewy body dementia and Alzheimer's disease

Firbank

Kobeleva

Cherry

et al. 2015

Human Brain Mapping

View full text Add to dashboard Cite

Attentional and executive dysfunction contribute to cognitive impairment in both Lewy body dementia and Alzheimer's disease. Using functional MRI, we examined the neural correlates of three components of attention (alerting, orienting, and executive/conflict function) in 23 patients with Alzheimer's disease, 32 patients with Lewy body dementia (19 with dementia with Lewy bodies and 13 with Parkinson's disease with dementia), and 23 healthy controls using a modified Attention Network Test. Although the functional MRI demonstrated a similar fronto‐parieto‐occipital network activation in all groups, Alzheimer's disease and Lewy body dementia patients had greater activation of this network for incongruent and more difficult trials, which were also accompanied by slower reaction times. There was no recruitment of additional brain regions or, conversely, regional deficits in brain activation. The default mode network, however, displayed diverging activity patterns in the dementia groups. The Alzheimer's disease group had limited task related deactivations of the default mode network, whereas patients with Lewy body dementia showed heightened deactivation to all trials, which might be an attempt to allocate neural resources to impaired attentional networks. We posit that, despite a common endpoint of attention‐executive disturbances in both dementias, the pathophysiological basis of these is very different between these diseases. Hum Brain Mapp 37:1254–1270, 2016. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

show abstract

P4‐356: Decreased activation along the dorsal visual pathway after three month treatment with galantamine in mild Alzheimer's disease: An fMRI study

Cited by 2 publications

References 0 publications

Long reaction times are associated with delayed brain activity in lewy body dementia

Long reaction times are associated with delayed brain activity in lewy body dementia

Neural correlates of attention‐executive dysfunction in lewy body dementia and Alzheimer's disease

Contact Info

Product

Resources

About