p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma

Alomari, Ahmed K.; Glusac, Earl J.; McNiff, Jennifer M.

doi:10.1111/cup.12388

Cited by 35 publications

(20 citation statements)

References 30 publications

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“…Another commonly used marker to establish epithelial lineage is p63, a member of the p53 gene superfamily . A recent study suggested that p40 appears equally sensitive and more specific for SCC compared with MNF116 and p63 . Our and others experience indicate that immunohistochemical markers for keratinocytes such as 34beta E12, p63, p40, MNF116 and AE1/3 should be performed in order to exclude poorly differentiated SCC with osteoclastic giant cell reaction in the lesions with osteoclastic giant cell reaction even without obvious keratinization.…”

Section: Discussionmentioning

confidence: 86%

Squamous cell carcinoma with osteoclast‐like giant cells: a morphologically heterologous group including carcinosarcoma and squamous cell carcinoma with stromal changes

et al. 2015

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Cutaneous squamous cell carcinoma (SCC) with osteoclast-like giant cells (hereafter, osteoclastic cells) is very rare; eight cases have been reported since 2006. Whether the osteoclastic cells represents a reactive or neoplastic change remains a matter of debate. Osteoclastic cells are often observed in the sarcomatous component of cutaneous carcinosarcoma. SCC with osteoclastic cells is a heterogeneous condition that includes SCC with stromal changes containing osteoclastic cells (also known as osteoclast-like giant cell reaction) and carcinosarcoma. In some cases, SCC with an associated osteoclast-like giant cell reaction has been differentiated from carcinosarcoma based on the degree of cytologic atypia in non-epithelial components. We summarized the clinical and histopathologic characteristics of 11 patients of SCC with osteoclastic cells, including our two cases of SCC with an osteoclast-like giant cell reaction and one case of carcinosarcoma. The affected patients were old and more likely to be male (64%). Seven cases (64%) were in the head and neck. Moreover, multiple features of high risk SCC were observed, such as a tumor size greater than 2 cm (56%), moderate or poor differentiation (100%), recurrence (33%) and nodal metastasis (17%) after excision and immunosuppression (27%). Interestingly, half of the previously reported cases of SCC with osteoclastic giant cell reaction had histopathologic findings that were overlapping with those of carcinosarcoma.

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Section: Discussionmentioning

confidence: 86%

Squamous cell carcinoma with osteoclast‐like giant cells: a morphologically heterologous group including carcinosarcoma and squamous cell carcinoma with stromal changes

et al. 2015

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“…Metastatic anaplastic thyroid carcinoma with only a spindle cell component may require an initial immunohistochemical panel with S100, SOX‐10, pancytokeratin, CD68, CD10, p63 and desmin to exclude other spindle cell malignancies of the skin. The addition of PAX‐8 may aid in the diagnosis of cutaneous metastasis of anaplastic thyroid carcinoma, particularly if the tumor is composed exclusively of spindle cells …”

Section: Resultsmentioning

confidence: 99%

Cutaneous metastasis from anaplastic thyroid carcinoma exhibiting exclusively a spindle cell morphology. A case report and review of literature

et al. 2015

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Anaplastic thyroid carcinoma is a highly aggressive cancer accounting for 1-2% of thyroid malignancies. Cutaneous metastases from anaplastic thyroid carcinoma are exceedingly rare. We report a 65-year-old woman with anaplastic thyroid carcinoma (BRAF V600E mutation) who had lymph node metastases (pT4 N1b) treated by total thyroidectomy, postoperative radiotherapy, adjuvant chemotherapy (paclitaxel and pazopanib) and targeted therapy (vemurafenib). Nine months after initial diagnosis, radiographic studies revealed multiple pulmonary metastases. A dermatologic examination showed a solitary 1.2-cm chest nodule. Skin biopsy from this nodule revealed infiltrative dermal spindle cells arranged in poorly formed fascicles. Immunohistochemical studies demonstrated the tumor cells to be PAX-8 (+), pancytokeratin (+, focally), TTF-1 (-) and SOX-10 (-). Comparison with the patient's primary anaplastic thyroid carcinoma revealed focal areas of poorly differentiated spindle cells morphologically similar to the malignant spindle cells in the skin biopsy. Together, these findings confirmed the diagnosis of anaplastic thyroid carcinoma metastatic to skin. Cutaneous metastasis of anaplastic thyroid carcinoma composed exclusively of spindle cells broadens the histologic differential diagnosis of cutaneous spindle cell malignancies and presents further diagnostic challenges. PAX-8 may be useful in discerning the spindle cell component of anaplastic thyroid carcinoma from other spindle cell malignancies in the skin.

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“…The absence of S100 and Melan‐A immunostaining, and the diffuse immunoreactivity for two smooth muscle markers (SMA and HHF‐35 muscle‐specific antigen), as well as the presence of focal calponin immunostaining, together with the expression of low‐molecular‐weight cytokeratins (such as CK8) excluded melanoma, atypical fibroxanthoma and pleomorphic dermal sarcoma, and favoured LMS; the latter was also supported by the histological features. The absence of p63, p40 and high‐molecular‐weight cytokeratins was critical to exclude squamous cell carcinoma …”

Section: Discussionmentioning

confidence: 99%

Red crateriform tumour on the scalp

González-Delgado¹,

Cordero-Romero²,

Monteagudo

et al. 2018

Clin Exp Dermatol

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p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma

Cited by 35 publications

References 30 publications

Squamous cell carcinoma with osteoclast‐like giant cells: a morphologically heterologous group including carcinosarcoma and squamous cell carcinoma with stromal changes

Squamous cell carcinoma with osteoclast‐like giant cells: a morphologically heterologous group including carcinosarcoma and squamous cell carcinoma with stromal changes

Cutaneous metastasis from anaplastic thyroid carcinoma exhibiting exclusively a spindle cell morphology. A case report and review of literature

Red crateriform tumour on the scalp

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