P428: The Fatty Acid Elongase Elovl6 Is Crucial for Hematopoietic Stem Cell Engraftment and Leukemia Propagation

Abstract

Lipid metabolism plays an essential role in regulating stem and cancer cell function. The enzyme ELOVL6 converts C16 saturated and monounsaturated fatty acids (FAs) to C18 species, the most important step for the de novo synthesis of endogenous long chain FAs. Variations in carbon chain length or degree of desaturation of FA greatly contribute to lipid diversity. However, whether the lipid diversity significantly regulates hematopoietic cell biology remains unknown.