P43 Acetazolamide response in patients affected by hypokalemic periodic paralysis

Portaro, Simona; Matthews, Emma; Sud, Richa; Davis, MB; Hanna, Michael G.

doi:10.1016/s0960-8966(10)70058-4

Cited by 1 publication

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“…1,9 It should be noted that about 50% of genotyped patients respond to acetazolamide, most with the Ca 2þ channel mutation, exacerbation of the condition being reported with its use in patients with the Na þ channel mutation. 1,10 An attack can be staved off with commencement of gentle exercise at its onset, but the mainstay of treatment acutely is K þ replacement, either orally with 0.2-0.4 mmol/kg every 30 minutes (maximum 250 mmol per day) or intravenously with 40 mmol/L in 5% mannitol at 20 mmol/hour (maximum 250 mmol per day). 1 HypoKPP and pregnancy.…”

Section: Features Of Hypokppmentioning

confidence: 99%

Anaesthetic management of a parturient with hypokalaemic periodic paralysis for caesarean section: A case report and review of the literature

Vassiliadis

2024

Anaesth Intensive Care

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A 32-year-old multigravida woman, with known familial hypokalaemic periodic paralysis, underwent spinal anaesthesia for an elective lower segment caesarean section. There are several case reports in the literature discussing the optimal anaesthetic technique. In the past there has not been an emphasis on aggressive and early potassium replacement. A target level to commence replacement of potassium at 4.0 mmol/L or less is proposed. Careful preoperative preparation, frequent perioperative monitoring and early potassium replacement resulted in no perioperative episodes of weakness in this case, in contrast with other case reports where potassium was either not monitored or not replaced early enough, resulting in postoperative attacks. Another factor to consider in hypokalaemic periodic paralysis is the avoidance of triggers, including certain medications. Misoprostol was used in this instance to avoid potential electrolyte derangements from other uterotonics.

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Section: Features Of Hypokppmentioning

confidence: 99%

Anaesthetic management of a parturient with hypokalaemic periodic paralysis for caesarean section: A case report and review of the literature

Vassiliadis

2024

Anaesth Intensive Care

View full text Add to dashboard Cite

show abstract

P43 Acetazolamide response in patients affected by hypokalemic periodic paralysis

Cited by 1 publication

References 0 publications

Anaesthetic management of a parturient with hypokalaemic periodic paralysis for caesarean section: A case report and review of the literature

Anaesthetic management of a parturient with hypokalaemic periodic paralysis for caesarean section: A case report and review of the literature

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