p43 induces IP-10 expression through the JAK-STAT signaling pathway in HMEC-1 cells

Wang, Wei; Tan, Junjie; Xing, Yufeng; Kan, Naipeng; Ling, Jingyi; Dong, G.F.; Liu, Gang; Chen, Huipeng

doi:10.3892/ijmm.2016.2710

Cited by 8 publications

(8 citation statements)

References 33 publications

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“…In addition, several other molecules pertinent to RA pathology are also regulated by JAK/STAT signaling. These include, IP-10, 99 TNFRSF12, a mediator of apoptosis 100 and IL-15. 101 In fact, Shenoy and colleagues, 102 showed that IL-15 regulated the Bcl-2 family proteins, Bim and Mcl-1 in T-cells.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The role of the JAK/STAT signal pathway in rheumatoid arthritis

Malemud

2018

Therapeutic Advances in Musculoskeletal

221

137

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Proinflammatory cytokine activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signal transduction pathway is a critical event in the pathogenesis and progression of rheumatoid arthritis. Under normal conditions, JAK/STAT signaling reflects the influence of negative regulators of JAK/STAT, exemplified by the suppressor of cytokine signaling and protein inhibitor of activated STAT. However, in rheumatoid arthritis (RA) both of these regulators are dysfunctional. Thus, continuous activation of JAK/STAT signaling in RA synovial joints results in the elevated level of matrix metalloproteinase gene expression, increased frequency of apoptotic chondrocytes and most prominently 'apoptosis resistance' in the inflamed synovial tissue. Tofacitinib, a JAK small molecule inhibitor, with selectivity for JAK2/JAK3 was approved by the United States Food and Drug Administration (US FDA) for the therapy of RA. Importantly, tofacitinib has demonstrated significant clinical efficacy for RA in the post-US FDA-approval surveillance period. Of note, the success of tofacitinib has spurred the development of JAK1, JAK2 and other JAK3-selective small molecule inhibitors, some of which have also entered the clinical setting, whereas other JAK inhibitors are currently being evaluated in RA clinical trials.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The role of the JAK/STAT signal pathway in rheumatoid arthritis

Malemud

2018

Therapeutic Advances in Musculoskeletal

221

137

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“…Whereas, the other cytokine trends indicate possible reversible action as variable expression patterns are viewed across time points. IP-10 and MIP-1b have known interactions and roles with the JAK/STAT protein pathway [24,25]. The JAK/STAT canonical pathway is a system of linked interactions involved in the phosphorylation of tyrosine residues in receptors creating active binding sites for proteins with Src-Homology (SH2) domains.…”

Section: Secreted Molecules Role In Signalling Pathways Controlling Nmentioning

confidence: 99%

Valproic Acid Promotes Early Neural Differentiation in Adult Mesenchymal Stem Cells Through Protein Signalling Pathways

Santos

Hubert

Milthorpe

2020

Cells

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Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown the capacity to differentiate into several cell types applicable for regenerative medicine (specifically neural cells, using chemicals). Valproic acid was an ideal candidate due to its clinical stability. It has been implicated in the induction of neural differentiation; however, the mechanism and the downstream events were not known. In this study, we showed that using valproic acid on adult mesenchymal stem cells induced neural differentiation within 24 h by upregulating the expression of suppressor of cytokine signaling 5 (SOCS5) and Fibroblast growth factor 21 (FGF21), without increasing the potential death rate of the cells. Through this, the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is downregulated, and the mitogen-activated protein kinase (MAPK) cascade is activated. The bioinformatics analyses revealed the expression of several neuro-specific proteins as well as a range of functional and structural proteins involved in the formation and development of the neural cells.

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“…On the other hand, high levels of AIMP1 activated c-Jun N-terminal kinase (JNK), which caused endothelial cells to undergo apoptosis. 54,62 The JAK-STAT signaling system automatically mediated the inhibitory effects of AIMP1 on angiogenesis. Also, it was found that AIMP1 is synthesized by pancreatic cells when the blood glucose level is less than 100 mg/dL.…”

Section: Catalytic Domain/new Additional Domainmentioning

confidence: 99%

Aminoacyl‐tRNA synthetase – a molecular multitasker

Gupta,

Jani,

Vijayasurya

et al. 2023

The FASEB Journal

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Aminoacyl‐tRNA synthetases (AaRSs) are valuable “housekeeping” enzymes that ensure the accurate transmission of genetic information in living cells, where they aminoacylated tRNA molecules with their cognate amino acid and provide substrates for protein biosynthesis. In addition to their translational or canonical function, they contribute to nontranslational/moonlighting functions, which are mediated by the presence of other domains on the proteins. This was supported by several reports which claim that AaRS has a significant role in gene transcription, apoptosis, translation, and RNA splicing regulation. Noncanonical/ nontranslational functions of AaRSs also include their roles in regulating angiogenesis, inflammation, cancer, and other major physio‐pathological processes. Multiple AaRSs are also associated with a broad range of physiological and pathological processes; a few even serve as cytokines. Therefore, the multifunctional nature of AaRSs suggests their potential as viable therapeutic targets as well. Here, our discussion will encompass a range of noncanonical functions attributed to Aminoacyl‐tRNA Synthetases (AaRSs), highlighting their links with a diverse array of human diseases.

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p43 induces IP-10 expression through the JAK-STAT signaling pathway in HMEC-1 cells

Cited by 8 publications

References 33 publications

The role of the JAK/STAT signal pathway in rheumatoid arthritis

The role of the JAK/STAT signal pathway in rheumatoid arthritis

Valproic Acid Promotes Early Neural Differentiation in Adult Mesenchymal Stem Cells Through Protein Signalling Pathways

Aminoacyl‐tRNA synthetase – a molecular multitasker

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