P472 Impact of anti-TNF-alfa therapy on colectomy rates and indications for surgery in Ulcerative Colitis: Comparison of two patient cohorts from 2005 to 2007 and 2014 to 2016

Kolehmainen, Sara; Lepistö, Anna; Färkkilä, M.

doi:10.1093/ecco-jcc/jjx180.599

Cited by 2 publications

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“…A systematic review of population studies has suggested that the rate of colectomy for UC has reduced since the 1950s due to advances in medical therapy 6 . Biological medications such as infliximab have proved effective as rescue therapy in acute UC, with clinical trials reporting data on colectomy rates up to two years after treatment for moderate and severe colitis suggesting a reduction in colectomy rate vs placebo 7‐9 . The National Institute for Clinical Excellence (NICE) first licenced infliximab use in the NHS for patients with moderate to severe UC in December 2008 10 .…”

Section: Introductionmentioning

confidence: 99%

Colectomy rates for ulcerative colitis in England 2003‐2016

Worley

Almoudaris

Bassett

et al. 2020

Aliment Pharmacol Ther

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Summary Background Temporal trends in colectomy rate for ulcerative colitis (UC) are particularly relevant in the current era of published IBD standards and changing approach to salvage of acute severe disease. Aims To investigate temporal trends in colectomy for UC using English population data. Methods The Hospital Episode Statistics (HES) were interrogated between 2003‐2016 with two patient groups investigated independently. An ‘emergency’ cohort: emergency UC admission ≥ three days, age ≥18 and a ‘total population’ cohort: all English patients undergoing colectomy for UC. Mixed methods analyses were utilised. Results Emergency cohort: 37 981 patients, 49% female, median age 46. The one‐ and three‐year incidence of colectomy after acute admission was 0.17 and 0.21. Interrupted time series (ITS) analysis suggested reductions in colectomy rate of 4% per year after 2008 at 30 and 90 days following emergency admission, with no significant reduction ≥1 year. Mortality and laparoscopy rates improved when avoiding colectomy at index and emergency admissions; however, the proportion of emergency colectomies after salvage at index admission significantly increased during the study period. Total population cohort: 17 580 patients underwent colectomy for UC between 2003 and 2016, demonstrating a 3.1% annual reduction in total and elective colectomies after 2008, but no reduction in emergency colectomies. Conclusion Reductions in short‐term colectomy rates after emergency admission for UC do not persist beyond one year. Emergency colectomy rates remain unchanged. Reduced rates are probably due to multi‐modal improvements in IBD care. A lack of data regarding disease severity precludes further interpretation of appropriate medical salvage and timely surgery.

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Section: Introductionmentioning

confidence: 99%