P509 Posterior reversible encephalopathy syndrome (PRES) in a child with steroid-dependent nephrotic syndrome: a case report

Bottoni, Anthea; Sica, Felice; Basilone, A.; Chiossi, Lorenza; Damiano, B.; Ficele, L.; Marinari, Alessandra; Soldano, Lucia; Pettoello‐Mantovani, Massimo; Campanozzi, Angelo

doi:10.1136/archdischild-2019-epa.845

Cited by 2 publications

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“…Other studies also state that PRES should be one of the differential diagnosis in a child with nephrotic syndrome, if presented with headache and visual disturbance. 6,7 The exact pathophysiological mechanism of PRES is still not clear. Three hypotheses have been suggested, which include: first, after exposure to causative agent (severe hypertension), auto regulation mechanism of intracranial pressure fails, leading to vasogenic edema; second, after exposure to causative agent (mild-to-moderate hypertension), cerebral vasoconstriction and hypo perfusion cause vasogenic brain edema and ischaemia; third, endothelial injury with disruption of the bloodbrain barrier leads to fluid and protein transudation in the brain.…”

Section: Discussionmentioning

confidence: 99%

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Steroid Sensitive Nephrotic Syndrome Presented as Posterior Reversible Encephalopathy Syndrome - A Rare Case Report

Abhinay

Shankar

Rao

et al. 2020

J. Nepal Paedtr. Soc.

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Posterior reversible encephalopathy syndrome (PRES) is a rare serious syndrome of central nervous system that can develop in both adults and children. It is characterised by acute onset of headache, confusion, seizures, or focal neurological deficits along with radiological abnormalities in the parietal and occipital lobes. In the past, this syndrome has been mainly described in adults but rare in children. However, it is not uncommon in paediatric nephrology. Hypertension, renal disease, immunosuppression, and chemotherapy of malignancies are triggers for PRES. Here, we report a case of 12 years old boy with steroid-sensitive nephrotic syndrome presenting as PRES.

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Section: Discussionmentioning

confidence: 99%

“…PRES with nephrotic syndrome has mostly been associated with steroid dependent 6,7 and resistant nephrotic syndrome or it may develop during the course of illness. We reported this case as this was a very rare presentation of very common disease nephrotic syndrome presenting as PRES.…”

Section: Discussionmentioning

confidence: 99%