p53 and breast cancer, an update

Abstract

Abstractp53 plays a key role in mediating cell response to various stresses, mainly by inducing or repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA repair, and angiogenesis. According to this important function, p53 activity is controlled in a very complex manner, including several auto-regulatory loops, through the intervention of dozens of modulator proteins (the 'p53 interactome'). p53 mutations are observed in a significant minority of breast tumours. In the remaining cases, alterations of interactome components or target genes could contribute, to some extent, to reduce the ability of p53 to efficiently manage stress events. While the prognostic and predictive value of p53 is still debated, there is an increasing interest for p53-based therapies. The present paper aims to provide updated information on p53 regulation and function, with specific interest on its role in breast cancer.

Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

“…To characterize the molecular differences between these two groups of cell lines, we first listed the cell lines' molecular status and subtypes (Table 1; refs. [15][16][17][18]. A previous study suggested that NVP-BEZ235 induces cell death in breast cancer cells with PIK3CA mutations or HER2 amplification, whereas all of the PTEN deleted, mutated, or silenced cell lines are insensitive to NVP-BEZ235 (5).…”

Therapeutic Applications of Camel’s Milk and Urine against Cancer: Current Development Efforts and Future Perspectives

“…Lactoferrin is found to bind with insulin-like growth factor-binding protein-3 [97], thereby act by altering the availability or stability of insulin-like growth factor, a known regulator of the phosphatidylinositol 3-kinase/Akt pathway [98]. Accordingly, camel urine possess supreme anti-proliferative effect on many lines of cancer cell possibly through the induction of the cyclin dependent kinase inhibitor p21 as it is found to up-regulates p21 in the p53-defective cancer cells [39,99]. Anti-proliferative effect of camel urine is significantly influenced by breeds, age, sex and other camel characteristics.…”

The Nucleolar Protein Myb-binding Protein 1A (MYBBP1A) Enhances p53 Tetramerization and Acetylation in Response to Nucleolar Disruption

“…Physiological Significance of p53 Activation by MYBBP1A-p53 plays a critical role in cancer prevention, given that p53 suppresses tumorigenesis by inducing cell cycle arrest and apoptosis through its transcriptional activity (71). We recently demonstrated that MYBBP1A plays a role in tumor prevention in the context of p53 activation (72).…”