p53 and Ki‐67 as markers of radioresistance in head and neck carcinoma

Abstract

A deficiency of succinate dehydrogenase is a rare cause of mitochondrial encephalomyopathy. Three patients, 2 sisters and 1 boy from an unrelated family, presented with symptoms and magnetic resonance imaging signs of leukoencephalopathy. Localized proton magnetic resonance spectroscopy indicated a prominent singlet at 2.40ppm in cerebral and cerebellar white matter not present in gray matter or basal ganglia. The signal was also elevated in cerebrospinal fluid and could be identified as originating from the two equivalent methylene groups of succinate. Subsequently, an isolated deficiency of complex II (succinate:ubiquinone oxidoreductase) was demonstrated in 2 patients in muscle and fibroblasts. One of the sisters died at the age of 18 months. Postmortem examination showed the neuropathological characteristics of Leigh syndrome. Her younger sister, now 12 months old, is also severely affected; the boy, now 6 years old, follows a milder, fluctuating clinical course. Magnetic resonance spectroscopy provides a characteristic pattern in succinate dehydrogenase deficiency.

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

“…Evidence has shown that Ki-67 may be a potential marker for radiosensitivity in head and neck carcinomas when using a cutoff point at o20 or X20% (Raybaud-Diogene et al, 1997;Grabenbauer et al, 1998;Couture et al, 2002). Koelbl et al (2001), however, did not find a correlation between Ki-67 expression and radiation response, but an improved local control in tumours with complete response after radiotherapy (40 Gy).…”

“…Several studies have provided evidence that with a higher proliferative activity, head and neck cancers may respond significantly better to radiotherapy (Raybaud-Diogene et al, 1997;Grabenbauer et al, 1998;Kropveld et al, 1998;Couture et al, 2002). Evidence has shown that Ki-67 may be a potential marker for radiosensitivity in head and neck carcinomas when using a cutoff point at o20 or X20% (Raybaud-Diogene et al, 1997;Grabenbauer et al, 1998;Couture et al, 2002).…”

Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas

“…31 It also predicted response to neoadjuvant anthracycline-based chemotherapy in breast cancer 32 and response to radiation therapy in head and neck cancer. 16,33 In advanced ovarian carcinoma, high Ki-67 index was predictive of recurrence 34 and poor prognosis. 35,36 However, as in our study, low proliferation predicted poor response to chemotherapy in ovarian carcinomas.…”

“…16 The relationship between marker expression and patients' age, tumor grade, tumor size and the type of chemotherapy received was evaluated by the w 2 t-test. Cox regression analyses were performed to estimate the association between tumor expression and progression free survival.…”

Correlation of Ki-67 Proliferative Antigen Expression and Tumor Response to Induction Chemotherapy Containing Cell Cycle-Specific Agents in Head and Neck Squamous Cell Carcinoma

“…Ki-67 is a measure of the proliferative potential of several cancers, including HNSCC [17]. Ki-67 protein expression is not used as prognostic or predictive factors in HNSCC because studies evaluating Ki-67 for these purposes have been inconclusive [17][18][19][20][21][22]. However, in breast cancer, Ki-67 expression is significantly associated with a robust tumor response to hormone therapy and anthracycline-based neoadjuvant chemotherapy [23,24].…”