p53 Autoantibodies and Cancer: Specificity, Diagnosis and Monitoring

Flammann, H.T.; Kuhn, Hella-Monika

doi:10.1016/b978-044450331-2/50020-5

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…p53 is a tumor suppressor gene that plays a critical role in oncology. Its protein participates in the regulation of the cell-cycle, acts as a transcriptional transactivator/repressor, helps in DNA repair, suppresses cell growth, induces apoptosis and has many other functions [ 98 ]. The production of anti-p53 autoantibodies is strongly related to p53 protein overexpression in the tumor tissue [ 99 ].…”

Section: Autoantibodies As Markers Of Gastric Cancermentioning

confidence: 99%

Autoimmunity and Gastric Cancer

Bizzaro¹,

Antico²,

Villalta

2018

IJMS

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Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid. Here, we review the association of autoimmune gastritis with gastric cancer and other autoimmune features present in gastric neoplasms.

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Section: Autoantibodies As Markers Of Gastric Cancermentioning

confidence: 99%

Autoimmunity and Gastric Cancer

Bizzaro¹,

Antico²,

Villalta

2018

IJMS

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“…Anti-p53 antibodies, which are first reported in patients with breast cancer, correlate significantly with the tumor suppressor gene p53 protein expression, demonstrating about 96% specificity for neoplastic detection. In contrast to anti-carcinoembryonic antigen (CEA) anti-survivin, anti-mucin, and anti-livin autoantibodies, anti-p53 antibodies are not appropriate markers for early diagnosis and prognosis as they are detected in advanced gastric tumors with regional lymph node involvement [123,126,[132][133][134]. DOI: http://dx.doi.org/10.…”

Section: Gastric Cancermentioning

confidence: 99%

Current View on Autoimmune Gastritis

Kovacheva-Slavova¹,

Angelov²,

Valkov³

et al. 2019

Gastritis - New Approaches and Treatments

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Autoimmune gastritis (AIG) is a chronic inflammatory disease of the gastric corpus and fundus. Although still unclear, genetic and environmental factors, antigenic mimicry or cross-reactivity are proposed pathogenic mechanisms. Parietal cells destruction results in loss of intrinsic factor and increased gastric pH due to hypochlorhydria and G-cell proliferation. Furthermore, atrophy, intestinal, pancreatic and spasmolytic polypeptide-expressing metaplasia are observed. AIG is underdiagnosed, however, proper diagnostic approach, including endoscopic, serological and histopathological assessment, is required. Gastroscopy with corpus and fundus biopsies is a gold standard. A serological combination of anti-parietal cell antibodies, intrinsic factor antibody, anti-Helicobacter pylori IgG, gastrin, pepsinogen I and pepsinogen I/II ratio improves the diagnostic sensitivity and specificity and allows atrophy level prediction. AIG might manifest with multifactorial iron deficiency anemia, vitamin B12 deficiency (pernicious anemia), neurological and neuropsychiatric conditions, small intestinal bacterial overgrowth and gastrointestinal infections. AIG association with other autoimmune diseases is wellestablished. Gastric cancer and gastric carcinoid are neoplastic transformations of a continuous chronic inflammation. Patients with AIG should be carefully monitored as no specific AIG therapy is available and disease complication could be fatal.

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Gut immunoglobulin alpha anti-glycan binding profiles as a research tool for local disease detection

et al. 2018

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A promising approach capitalizing on the specific and highly sensitive characteristics of the body's own immune system is demonstrated in the context of revealing pancreatic ductal adenocarcinoma cancer (PDAC). IgA from a local biofluid called gastrointestinal lavage fluid (GLF) is used to investigate glycan reactivity to show the potential of this approach. IgA antibody responses, just as with IgG, result in amplification of a small signal which aids in detecting changes from a healthy state. IgA from GLF was screened against glycan arrays containing 609 glycan structures to investigate differential binding patterns associated with the disease. Samples included PDAC (n = 14) and non-PDAC (n = 6). Non-PDAC conditions included samples from healthy patients and the potentially confounding conditions of colon cancer and its precancerous lesion, colon adenoma. Results demonstrated characteristic reactivity in the PDAC sample group to a glycan structure. Also, IgA non-reactive motifs arose showing remarkable consistency within and between sample groups. While sample sizes are too small to identify putative biomarkers, these data show the use of IgA from GLF to be a promising avenue of research for local disease biomarker discovery.

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p53 Autoantibodies and Cancer: Specificity, Diagnosis and Monitoring

Cited by 3 publications

References 66 publications

Autoimmunity and Gastric Cancer

Autoimmunity and Gastric Cancer

Current View on Autoimmune Gastritis

Gut immunoglobulin alpha anti-glycan binding profiles as a research tool for local disease detection

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