P53 codon 72 Arg/Pro polymorphism and lung cancer risk in Asians: an updated meta-analysis

Wang, Siyang; Xin-gang, Lan; Tan, Suxu; Si-wen, Wang; Li, Yu

doi:10.1007/s13277-013-0678-2

Cited by 17 publications

(11 citation statements)

References 34 publications

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“…In a metaanalysis of 51 studies, polymorphism TP53 Arg72Pro (rs1042522) was significantly associated with lung cancer risk in any genetic model (Ye et al, 2014). According to S. Wang et al (2013), the Arg72Pro genotype positively correlated with lung cancer risk in Asians. Only few studies attempted to determine the impact of polymorphism TP53 Arg72Pro (rs1042522) on cancer risk in the Kazakh population.…”

Section: Discussionmentioning

confidence: 99%

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Association of polymorphism TP53 Arg72Pro with radon-induced lung cancer in the Kazakh population

et al. 2019

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Lung cancer is a problem of great concern and one of the commonest cancer diseases worldwide and in the Republic of Kazakhstan in particular. Radon exposure is classified as the second most important cause of lung cancer. According to the experts, the contribution of natural sources to the average annual radiation dose of the Kazakh population currently stands at 80 %, including 50 % from radon. However, the effect of radon on human health in the Republic of Kazakhstan is almost unknown. The tumor suppressor gene TP53 is a key mediator of the DNA damage response cascade following cell exposure to ionizing radiation. The common polymorphism TP53 Arg72Pro (rs1042522) is a risk factor for lung cancer in the Asian population, but until now no genetic association studies have been done in the Kazakh population. No information on the synergistic carcinogenic effect of radon exposure and polymorphism TP53 Arg72Pro (rs1042522) is available either. This paper presents the results of the study of association between alteration in the TP53 gene and radon-induced lung cancer risk in the Kazakh population. Genetic association was assessed in a case-control study including 44 radon-exposed patients with lung cancer, 41 patients with lung cancer without radon exposure and 42 age/sex-matched healthy controls. We found that polymorphism TP53 Arg72Pro (rs1042522) was associated with lung cancer risk in the Kazakh population (OR = 6.95, 95 % CI = 2.41–20.05). Individuals with the Arg72Pro genotype also showed a significantly higher risk of radon-induced lung cancer (OR = 8.6, 95 % CI = 2.6–28.59).

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Section: Discussionmentioning

confidence: 99%

“…The published data on the association between polymor phism TP53 Arg72Pro (rs1042522) and lung cancer risk in Asians remain controversial (Wang et al, 2013). Zhao et al (2018) have shown that the Pro72Pro genotype is associated with a higher risk of cancer due to poorer ability to induce apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphism TP53 Arg72Pro with radon-induced lung cancer in the Kazakh population

et al. 2019

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“…They found no significant association between p53 Codon 72 Arg/Pro polymorphism and risk of oral cancer ( 19 ). Wang et al performed a meta-analysis by pooling 14 publications and suggested that the p53 Codon 72 Arg/Pro polymorphism is a risk factor for lung cancer in the Asian population( 20 ). Zhou et al performed a meta-analysis by pooling 12 publications and suggested that the p53 Codon 72 polymorphism may be associated with gastric cancer among Asians, and they further indicated that difference in genotype distribution may be associated with the location, stage, and histological differentiation of gastric cancer( 21 ).…”

Section: Introductionmentioning

confidence: 99%

Association of p53 codon 72 Arg>Pro polymorphism and risk of cancer in Iranian population: A systematic review and meta-analysis

Roshani

Abdolahi

Rahmati

2017

Med. J. Islam. Republic Iran

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Background: Different studies have investigated the association between p53 codon 72 Arg>Pro polymorphism and cancer risk. Because of the lack of consensus of the results in individual studies, we conducted this meta-analysis by pooling all currently available case–control studies to estimate the effect of p53 codon 72 Arg/Pro polymorphism on cancer susceptibility in Iranian population. Methods: A comprehensive search was undertaken and primary data from all peer-reviewed journals indexed in PubMed, Google Scholar, Scopus, Magiran, Scientific Information Databank (SID), Iran Medex, and CAB abstract electronic were used to conduct this meta-analysis. We considered some exclusion and inclusion criteria to select the articles. Statistical heterogeneity was explored using the I-square. Publication bias was assessed graphically and statistically by Begg’s funnel plot and Egger test. All statistical analyses were performed using StatsDirect software and a two- tailed test. P-value less than 0.05 was considered statistically significant for any test. Results: Our dataset, which included 35 case-control studies, consisted of 2426 cancer cases and 2928 controls. Pooled OR and 95%CI indicated that codon 72 Arg>Pro polymorphism was not associated with odds of developing cancer among Iranian population in the dominant model (Pro/Pro+Arg/Pro vs. Arg/Arg: OR= 0.96, 95%CI= 0.74 to 1.24 chi2= 0.06, p= 0.8). Moreover, no significant association was detected in variant allele (Pro vs Arg: OR= 1.075, 95%CI= 0.91 to 1.25), homozygous (Pro/Pro vs Arg/Arg: OR=0.911 95%CI= 0.66 to 1.25), and heterozygous (Arg/Pro vs Arg/Arg: OR= 0.84, 95%CI= 0.7 to 1). Conclusion: Our study revealed that p53 codon 72 Arg>Pro polymorphism was not associated with overall cancer odds in Iranian population.

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“…Survival of lung cancer patients undergoing lung resection was more than 80%, which suggested that early detection and diagnosis helped immensely in the early treatment of lung cancer. 7 , 8 Increasing evidence has indicated that polymorphisms of numerous susceptible genes play a significant association in the development of lung cancer. Thus, these polymorphisms could be useful as biomarkers for lung cancer detection.…”

Section: Introductionmentioning

confidence: 99%

IL-10-1082A/G, -592C/A, and -819T/C polymorphisms in association with lung cancer susceptibility: a meta-analysis

Liu¹,

Zheng²

2016

OTT

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Numerous studies have examined the association between interleukin-10 (IL-10 -1082A/G, -592C/A, and -819T/C) gene polymorphisms and risk of lung cancer, but these have revealed inconsistent results. The aim of this study was to clarify the relationship between these polymorphisms and the risk of lung cancer by performing a meta-analysis. The published literature concerning IL-10 polymorphisms and lung cancer risk were retrieved by systematically searching PubMed, Embase, Web of Science, China National Knowledge Infrastructure, WanFang, and Database of Chinese Scientific and Technical Periodicals (VIP) database. Statistical analysis was conducted with Stata 12.0 software. A total of ten published articles comprising of 19 studies were selected, including seven studies (1,960 controls and 1,321 cases) for IL-10 -1082A/G, seven studies (2,613 controls and 1,839 cases) for IL-10 -592C/A, and five studies (1,558 controls and 926 cases) for IL-10 -819T/C. This study found that the IL-10 -1082A/G and -592C/A polymorphisms were significantly associated with the risk of lung cancer in the overall analysis. When stratified by ethnicity, significantly increased risks were observed for IL-10 -1082A/G, -592C/A, and -819T/C polymorphisms in Asians (for -1082A/G, AA vs [AG + GG]: odds ratio [OR] =1.20, confidence interval [CI] =1.05–1.39, P<0.05; for C-592A, C vs A, OR =1.36, CI =1.20–1.53, P<0.05; CC vs AA, OR =1.85, CI =1.45–2.37, P<0.05; CC vs [CA + AA], OR =1.36, CI =1.15–1.61, P<0.05; for -819T/C, T vs C: OR =1.21, CI =1.06–1.38, P<0.05; TT vs CC, OR =1.54, CI =1.18–2.01, P<0.05; [TT + TC] vs CC, OR =1.51, CI =1.17–1.95, P<0.05). Moreover, the data indicated that there was a significant association between IL-10 -819T/C polymorphism and non-small-cell lung cancer risk. No significant publication bias was detected under the four genetic models (allele model, homozygous model, dominant model, and recessive model) in this meta-analysis. On the basis of these 19 studies, this study found that the IL-10 -1082A/G and -819T/C polymorphisms might have a significant association with risk of lung cancer in Asian populations.

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P53 codon 72 Arg/Pro polymorphism and lung cancer risk in Asians: an updated meta-analysis

Cited by 17 publications

References 34 publications

Association of polymorphism <i>TP53</i> Arg72Pro with radon-induced lung cancer in the Kazakh population

Association of polymorphism <i>TP53</i> Arg72Pro with radon-induced lung cancer in the Kazakh population

Association of p53 codon 72 Arg>Pro polymorphism and risk of cancer in Iranian population: A systematic review and meta-analysis

<em>IL-10-1082A/G</em>, <em>-592C/A</em>, and <em>-819T/C</em> polymorphisms in association with lung cancer susceptibility: a meta-analysis

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