p53 codon 72 polymorphism and endometriosis: a meta-analysis

Jia, Shuting; Xu, Lin; Chan, Ying; Wu, Xiaoming; Yang, Shihua; Yu, Hua; Yang, Hongju; Luo, Ying; Tang, Wenru

doi:10.1007/s00404-012-2226-5

Cited by 13 publications

(8 citation statements)

References 39 publications

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“…This meta-analysis differs from a previous meta-analysis analyzing the relationship between the p53 codon 72 polymorphism and endometriosis risk performed by Jia et al (2012). Specifically, in the present report, 4 more studies (Bianco et al, 2011;Govatati et al, 2012;Paskulin et al, 2012;Ying et al, 2011), 1,196 more patients, and 1,299 more controls were included; and one study was excluded due to duplicate data (Hsieh & Lin, 2006).…”

Section: Test Of Associationcontrasting

confidence: 59%

A Meta-analysis of the Association between p53 Codon 72 Polymorphism and Susceptibility to Endometriosis

Song

Lee

2014

Immunological Investigations

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Section: Test Of Associationcontrasting

confidence: 59%

A Meta-analysis of the Association between p53 Codon 72 Polymorphism and Susceptibility to Endometriosis

Song

Lee

2014

Immunological Investigations

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“…Although two meta-analyses addressing the association between the TP53 codon 72 polymorphism and endometriosis risk have been published, this study's findings indicate that the TP53 codon 72 polymorphism is associated with endometriosis risk, especially in Asian and Latin American populations, which is in part in contrast to both Jia's and Song's results (Jia et al, 2012;Song and Lee, 2014). Compared with the previous studies, this current meta-analysis has several particular strengths.…”

Section: Discussioncontrasting

confidence: 61%

“…This polymorphism (rs1042522) shows a single nucleotide substitution of G to C, resulting in the shift of arginine to proline in the amino acidic sequence. Previously, two research groups conducted metaanalyses concerning this theme and presented the same conclusion that TP53 codon 72 polymorphism was associated with the endometriosis risk in Asian populations rather than overall and in Caucasian populations (Jia et al, 2012;Song and Lee, 2014). By including certain new cohorts (Camargo-Kosugi et al, 2014;Chan, 2013;Frare et al, 2013;Huang et al, 2013;Kang et al, 2004;Silva, 2012) and applying different approaches for subgroup analyses, this study conducted an updated meta-analysis in order to further clarify the association between TP53 codon 72 polymorphism and susceptibility of endometriosis.…”

Section: Introductionmentioning

confidence: 80%

The codon 72 polymorphism of the TP53 gene and endometriosis risk: a meta-analysis

Feng

et al. 2015

Reproductive BioMedicine Online

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“…A study performed in a Japanese population revealed that the Pro/Pro genotype at codon 72 was associated with increased risk of prostate cancer and its progression (35). Two separate meta-analyses by Jia et al (36) and Lao et al (37) suggested that the homozygote and heterozygote genotypes of Pro participated in the development of endometriosis in Asian and Caucasian populations. Analysis of this variant among an Iranian population revealed that the Arg genotype increased the risk of breast cancer while Pro served as a protective factor (38).…”

Section: Discussionmentioning

confidence: 99%

Association of P53 gene polymorphism with gastric cancer in Northern Iran as a high‑risk region

et al. 2018

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Abstract. Gastric cancer has the fourth highest morbidity rate of all cancers worldwide. Genetic factors including alterations in oncogenes and tumor suppressor genes serve an important role in gastric cancer development and progression. The P53 gene acts as a tumor suppressor gene by regulating the cell cycle, DNA transcription and repair, apoptosis, senescence and genome stability. In addition to somatic P53 mutations in cancer development, germline polymorphisms are also involved in different malignancies. The polymorphism of P53 at codon 72 (Arg72Pro) is established as a common variant that increases susceptibility to various cancers. The present case-control study was conducted to evaluate the possible association between this P53 polymorphism and gastric cancer in the Iranian population. A total of 59 patients with gastric cancer and 59 healthy controls were enrolled in the present study. Genomic DNA was extracted from peripheral blood mononuclear cells and genotype analysis was performed using a polymerase chain reaction-based restriction fragment length polymorphism assay. Genotype frequencies did not differ significantly between the patients and controls (P=0.4); the frequencies of the three genotypes Arg/Arg, Arg/Pro and Pro/Pro in gastric cancer patients were 28.8, 49.2 and 22.0%, and in controls were 37.3, 49.2 and 13.6%. Additionally, there were no differences in genotype frequencies based on tumor location, histological differentiation or tumor stage. Based on these findings, it may be concluded that the P53 codon 72 polymorphism does not contribute to gastric cancer susceptibility in Northern Iran. IntroductionGastric cancer has the third highest mortality and fourth highest morbidity rates of all cancers worldwide (1). In 2012, GloboCan statistics reported almost 1 million new cases of gastric cancer, and more than 700,000 mortalities caused by gastric cancer (1). Gastric cancer is a multifactorial disorder, in which genetic and environmental interactions serve an important role in development and progression (2). Increasing age, gender, lifestyle, dietary regime, environmental factors and Helicobacter pylori infections are among the known risk factors for stomach cancer (3,4). While dietary regime and lifestyle are the most recognized factors, more effective identification of the genetic risk factors is expected to improve understanding of the basic molecular events involved in tumorigenesis (5). Various genetic and epigenetic changes that have the potential to convert normal epithelial cells in the stomach into malignant neoplasms may be responsible for the development of both familial and sporadic gastric cancer (6,7). Studies performed recently have demonstrated that a high number of genes and various environmental factors are the causal agents of gastric cancer, and the presence of different forms of alleles in genes (polymorphisms) may promote the development of cancers; in this regard, the P53 gene has been a research focus due to its role as a major tumor suppressor gene (8,9). The P53 ge...

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p53 codon 72 polymorphism and endometriosis: a meta-analysis

Abstract: This meta-analysis suggests that p53 codon 72 Pro/Pro + Arg/Pro genotypes are associated with increased risk of endometriosis in Asian. To validate the association between p53 codon 72 polymorphism and endometriosis, further studies with larger participants worldwide are needed.

Cited by 13 publications

References 39 publications

A Meta-analysis of the Association between p53 Codon 72 Polymorphism and Susceptibility to Endometriosis

A Meta-analysis of the Association between p53 Codon 72 Polymorphism and Susceptibility to Endometriosis

The codon 72 polymorphism of the TP53 gene and endometriosis risk: a meta-analysis

Association of P53 gene polymorphism with gastric cancer in Northern Iran as a high‑risk region

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