p53 Expression in Oral cancer: A study of 50 cases

Ghanghoria, Shikha; Ghanghoria, Arvind; Shukla, AK

doi:10.3126/jpn.v5i9.13785

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…In the present study p53 immunoexpression was noted in 62.1% of cases. The present study which was similar to the observations by Ghanghoria S et al 29 Umaswaminathan et al 30 Nighat Ara et al 23 where p53 expression was 63%,65%and 67% respectively, but expression of p53 was 20% higher in Nishat Sultana et al 31 where it was seen in 80% of cases.…”

Section: Discussionsupporting

confidence: 92%

Study of p53 gene over expression as a prognostic marker in squamous cell carcinoma of the oral cavity

2020

IJPO

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The present study entitled "Study of p53 gene expression as a prognostic marker in squamous cell carcinoma of oral cavity" was conducted in the department of pathology SRMSIMS Bareilly, 66 cases diagnosed on histopathology as squamous cell carcinoma of oral cavity from Jan 2016 to Jan 2017 were included in the study. Various parameters analysed for each case included age, gender, site, history of tobacco chewing, smoking &, alcohol consumption, histopathological grade of tumor and p53 expression. The patients age ranged from 24 to 85 years with mean age; 52.09 years and median age; 53 years. Maximum no of patients were male 54(81.8%) and 12 (18.2%) were female. Male: female ratio was 9:2. The most common site of presentation was lateral border of tongue (34.8). In the present study 89.4% were tobacco chewers, 72.7% were alcoholics and 57.6% were smokers.34 cases (51.5%) were diagnosed as well differentiated, 26 cases(39.4%) as moderately differentiated and 6 cases (9.1)% as poorly differentiated squamous cell carcinoma. The p53 expression was observed in 41(62.1%) of cases. The expression of p53 increased with the grade of tumor. The positivity being 17(50%) in cases of well differentiated, 19(73%) in moderately differentiated and 5(83%) in poorly differentiated squamous cell carcinoma. In present study p53 expression is found to be significantly related with tobacco chewing (p value= 0.034), smoking (p value= 0.0046) and tumor grade (p value=0.030). However no association was found with alcohol consumption (p value=0.917) the increasing prevalence of p53 expression with increasing grade of tumor suggests that it can be used as a prognostic indicator in oral cavity cancers.

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Section: Discussionsupporting

confidence: 92%

Study of p53 gene over expression as a prognostic marker in squamous cell carcinoma of the oral cavity

2020

IJPO

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“…The present study observed a statistically significant relation between p53 staining intensity and p53 protein expression in tissue samples of OSCC. These findings are in obedience with the findings noted by Ara et al, and Azizi et al, 23,26 Among OSCC lesions, a statistically insignificant relation was observed between tissue p53 immunoreactivity and WHO OSCC grading system, age, gender, tobacco usage history, type of tobacco product consumed frequency of tobacco use per day, and duration of tobacco use in years. These findings are in obedience with the observations reported by Bhattacharya et al 27 However, a study done by Gatto et al, revealed a statistically significant relation between p53 immunoreactivity and histological grades and tobacco and betel quid habits and insignificant relation with age, gender of OSCC lesion.…”

Section: 25supporting

confidence: 83%

Immunohistochemical Expression of P53 in Oral Squamous Cell Carcinoma, Oral Epithelial Precursor Lesions, and Normal Oral Mucosa

Khan

Ahmad

Iqbal

et al. 2022

JMS

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Abstract Objective: To assess the immunohistochemical expression of p53 in tissue samples of oral squamous cell carcinoma (OSCC), oral epithelial precursor lesions and normal oral mucosa. Methods: A comparative cross-sectional study was jointly conducted at the Departments of Pathology and Oral and Maxillofacial Surgery of various medical and dental institutes of the country from April 2016 to March 2017. A total of 180 subjects were included in the study. Oral tissue specimens were collected for lab investigations after obtaining written consent from all subjects. TP53 was assessed by means of immunohistochemistry in tissue samples of 60 cases of OSCC, 60 cases of epithelial precursor lesions and normal oral mucosal samples of 60 healthy individuals. Data was recorded, evaluated and analysed by SPSS version 20. Results: p53 protein expression was noted in 85% OSCC and 73% oral epithelial precursor lesions. Among healthy individuals ,one subject showed p53 immunoreactivity in normal oral mucosa. Conclusion: Raised TP53 overexpression in OSCC and oral precursor lesions, compared to normal oral mucosa make it a probable candidate for potential predictive biomarker in oral premalignancy and malignancy.

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“…On chromosome 17p 13.1 of humans, the p53 gene is located which encodes a 53-kDa, 393 AA, and nuclear phosphoproteins known for cell proliferation and regulation of cell growth [ 30 ]. Three hundred ninety-three amino acids of the human p53 protein contains four major functional domains.…”

Section: Resultsmentioning

confidence: 99%

Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma

2021

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Moringa oleifera is nowadays raising as the most preferred medicinal plant, as every part of the moringa plant has potential bioactive compounds which can be used as herbal medicines. Some bioactive compounds of M. oleifera possess potential anti-cancer properties which interact with the apoptosis protein p53 in cancer cell lines of oral squamous cell carcinoma. This research work focuses on the interaction among the selected bioactive compounds derived from M. oleifera with targeted apoptosis protein p53 from the apoptosis pathway to check whether the bioactive compound will induce apoptosis after the mutation in p53. To check the toxicity and drug-likeness of the selected bioactive compound derived from M. oleifera based on Lipinski’s Rule of Five. Detailed analysis of the 3D structure of apoptosis protein p53. To analyze protein’s active site by CASTp 3.0 server. Molecular docking and binding affinity were analyzed between protein p53 with selected bioactive compounds in order to find the most potential inhibitor against the target. This study shows the docking between the potential bioactive compounds with targeted apoptosis protein p53. Quercetin was the most potential bioactive compound whereas kaempferol shows poor affinity towards the targeted p53 protein in the apoptosis pathway. Thus, the objective of this research can provide an insight prediction towards M. oleifera derived bioactive compounds and target apoptosis protein p53 in the structural analysis for compound isolation and in-vivo experiments on the cancer cell line.

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p53 Expression in Oral cancer: A study of 50 cases

Cited by 11 publications

References 23 publications

Study of p53 gene over expression as a prognostic marker in squamous cell carcinoma of the oral cavity

Study of p53 gene over expression as a prognostic marker in squamous cell carcinoma of the oral cavity

Immunohistochemical Expression of P53 in Oral Squamous Cell Carcinoma, Oral Epithelial Precursor Lesions, and Normal Oral Mucosa

Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma

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