p53 mutation in histologically normal mucosa of the aero-digestive tract is not a marker of increased risk for second primary carcinoma in head and neck cancer patients

Escher, Anette; Piotet, Elsa; Waridel, François; Iggo, Richard; Monnier, Philippe

doi:10.1007/s00405-008-0780-z

Cited by 15 publications

(14 citation statements)

References 15 publications

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“…The functional implications of loss of normal p53 and/or altered p53/ p63 balance seem obvious; however, the possibility that p53 mutations can be a marker of expanding clones of cells, rather than an initial or obligate cancer-triggering event, should also be considered. Consistent with this possibility is the finding that, in patients with primary oral SCCs, the presence of cells with p53 mutations in the normal epithelium is not associated with increased risk of secondary tumors (51). Additionally, discordant p53 mutations can be found in multiple cancer lesions in the same patients (52).…”

Section: Epithelial Precursor Changesmentioning

confidence: 82%

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

Dotto¹

2014

J. Clin. Invest.

130

112

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It is increasingly evident that cancer results from altered organ homeostasis rather than from deregulated control of single cells or groups of cells. This applies especially to epithelial cancer, the most common form of human solid tumors and a major cause of cancer lethality. In the vast majority of cases, in situ epithelial cancer lesions do not progress into malignancy, even if they harbor many of the genetic changes found in invasive and metastatic tumors. While changes in tumor stroma are frequently viewed as secondary to changes in the epithelium, recent evidence indicates that they can play a primary role in both cancer progression and initiation. These processes may explain the phenomenon of field cancerization, i.e., the occurrence of multifocal and recurrent epithelial tumors that are preceded by and associated with widespread changes of surrounding tissue or organ "fields."

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Section: Epithelial Precursor Changesmentioning

confidence: 82%

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

Dotto¹

2014

J. Clin. Invest.

130

112

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“…According to Esher et al [47], patients with HNSCC have a low survival rate among some cancer types. In spite of new surgical techniques, such as radiotherapy and concomitant chemotherapy, there has not been a significant increase in survival rate [48-50].…”

Section: Discussionmentioning

confidence: 99%

The association between CBS 844ins68 polymorphism and head and neck squamous cell carcinoma risk – a case-control analysis

Galbiatti¹,

Ruiz²,

Raposo³

et al. 2010

aoms

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IntroductionSusceptibility to head and neck squamous cell carcinoma may be modified by functional polymorphisms in genes involved in the folate pathway, such as cystathionine beta-synthase (CBS). The CBS 844ins68 polymorphism is associated with DNA methylation changes and cancer development.Material and methodsA case-control retrospective study was conducted in 322 patients with head and neck squamous cell carcinoma and in 531 control subjects without cancer. The polymerase chain reaction-restriction fragment length polymorphism technique was used to genotype the polymorphism. For statistical analysis, χ2 test was conducted to examine whether the genotypic frequency of CBS 844ins68 was in Hardy-Weinberg equilibrium and multiple logistic regression was used for comparisons between groups, and for interactions between the polymorphism and risk factors and clinical histopathological parameters.ResultsNo significant difference in CBS 844ins68 genotypic distribution was observed between the groups. Age > 50 years, male gender and tobacco consumption were predictors of the disease with increased risk of 7.89 (95% CI: 5.56-11.21), 2.49 (95% CI: 1.72-3.62), 6.44 (95% CI: 4.63-8.96) and 2.29 times (95% CI: 1.71-3.06) respectively. There was no association between the distribution of the CBS 844ins68 genotype and risk factors for this disease. According to clinical histopathological parameters, CBS 884ins68 polymorphism presented high frequency in oral cavity (p < 0.05) and patients with the polymorphism presented less survival time (p < 0.05).ConclusionsWe concluded that the CBS 844ins68 polymorphism is not associated with HNSCC risk and there is increased risk of this disease in male gender individuals smokers aged over 50 years. In adittion, the polymorphism is more frequent in patients with oral cavity as primary site and in patients with less survival time.

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“…Although new surgical techniques, improved radiotherapy (RT) and use of concomitant chemotherapy improve locoregional control, improvement of survival has not been achieved over the last decades. 1 One of the main reasons for this lack of efficacy seems to be that, apart from failure of locoregional disease control, head and neck cancer patients are at high risk of developing second primary tumors (SPT) arising from the same dysplastic mucosal field. Some authors have described the multifocal occurrence of SCC of the upper aerodigestive tract, but in 1933, Lund 2 first reported the presence of SPT in 6% of patients with oral SCC.…”

Section: Introductionmentioning

confidence: 99%

Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature

Lopes

Aquino

Morais

et al. 2015

The Journal of Contemporary Dental Practice

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Aim: This manuscript aims to describe an unusual case of multiple second primary squamous cell carcinomas (SCCs) in several sites of the oral mucosa in a nonsmoker and nondrinker woman and to discuss the diagnostic criteria, clinicopathological aspects and outcome of second primary tumor (SPT). Background:Patients treated for SCC of the head and neck are at high risk for developing SPT arising from the same dysplastic mucosal field. Currently, there is no reliable method to predict which of the patients will develop SPT. Case description:A 64-year-old nonsmoker and nondrinker woman developed several second primary oral SCCs in 7 years of follow-up, most of them being synchronic, treated by surgery without and with chemotherapy and radiotherapy. Conclusion:Patients treated for SCC require a long-term and careful follow-up as the development of SPT contributes with significantly negative impact on the prognosis.Clinical significance: This report describes the diagnosis and management of a very unusual case of several SPTs affecting different sites of the oral mucosa in the same patient. Moreover, the patient had no apparent risk factors associated

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p53 mutation in histologically normal mucosa of the aero-digestive tract is not a marker of increased risk for second primary carcinoma in head and neck cancer patients

Cited by 15 publications

References 15 publications

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

The association between CBS 844ins68 polymorphism and head and neck squamous cell carcinoma risk – a case-control analysis

Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature

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