p53 Oncoprotein Expression and Gene Mutations in Some Keratoacanthomas

Perez, Maritza I.; Robins, Perry; Biria, Shahriar; Roco, John; Siegel, Eric; Pellicer, Ángel Antonio Blasco

doi:10.1001/archderm.1997.03890380061009

Cited by 25 publications

(12 citation statements)

References 33 publications

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“…22,23 Therefore, dysfunction of the p53 protein may allow the damaged DNA to replicate and result in proliferation of abnormal cells. [24][25][26] In the present study, overexpression of p21 Waf1/Cip1 was detected in all Bowen's disease patients, but not in DSP patients. The p21 Waf1/Cip1 -positive immunostaining may represent antecedent tumour invasion, and therefore may be considered an important event in the development of Bowen's disease.…”

Section: Discussioncontrasting

confidence: 38%

Overexpression of p2l^Waf1/Cip1immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis

Kawakami

Saito²,

Takahashi

1999

British Journal of Dermatology

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Disseminated superficial porokeratosis (DSP) consists of multiple small lesions of porokeratosis. Although the pathogenesis of DSP remains unclear, localized cloning of abnormal epidermis has been hypothesized. Malignant cutaneous neoplasms, especially Bowen's disease, have been frequently reported in DSP. Immunopositive p53 has been demonstrated in a variety of human malignant tumours, and its role in oncogenesis and tumour progression is thought to be important. p21Waf1/Cip1 is thought to mediate the signal of p53 induced by DNA damaging agents to arrest the cell cycle. To clarify the role of p53 and p21Waf1/Cip1 in Bowen's disease and DSP, we analysed 12 cases of Bowen's disease and eight cases of DSP by immunohistochemistry. In five of the 12 Bowen's disease patients and two of the eight DSP patients, positive p53 staining was detected. In contrast, whereas p21Waf1/Cip1 overexpression was detected in all Bowen's disease patients, it was not seen in DSP. The present data suggest that p53 immunostaining provides relevant information concerning the pathogenesis of Bowen's disease and DSP. Furthermore, high p21Waf1/Cip1 expression appears to be a useful indicator of tumour activity in Bowen's disease.

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Section: Discussioncontrasting

confidence: 38%

Overexpression of p2l^Waf1/Cip1immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis

Kawakami

Saito²,

Takahashi

1999

British Journal of Dermatology

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“…Gene alterations have been linked to KA as well as other skin cancers. 91,92 Expression of the bcl-2 protooncogene was found to be more marked with typical SCC than KA, suggesting the possibility that KA might be a SCC deficient in bcl-2 expression. 93 Expression of the cyclin-dependent kinase inhibitor p27 in KA may be an important factor.…”

Section: Etiology/pathogenesismentioning

confidence: 99%

Keratoacanthoma: A Clinico-Pathologic Enigma

2004

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“…Furthermore, both VC and SUKA show an identical pattern of ‘basal‐layer distributed’ immunohistochemical staining for Ki‐67 5,6 , 27 . Staining for p53 may be positive in both VC and extra‐onychal KA; 17,28 one might predict the same in SUKA, although there are no studies to confirm this.…”

Section: Discussionmentioning

confidence: 97%

Squamous cell carcinoma arising in a psoriatic nail bed: case report with discussion of diagnostic difficulties and therapeutic options

Dobson

Azurdia²,

King³

2002

Br J Dermatol

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We describe a squamous cell carcinoma arising from a psoriatic nail bed. The tumour had a verrucous surface and was very well differentiated, raising the possibility of early verrucous carcinoma. Occurrence of any type of squamous carcinoma in this site and background is extremely rare. Particular diagnostic and therapeutic questions arise in this unusual setting. We discuss the aetiology and diagnostic differentiation from other nail bed squamoproliferative lesions, particularly so-called subungual keratoacanthoma. We also discuss therapeutic options, including Moh's surgery and retinoids.

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p53 Oncoprotein Expression and Gene Mutations in Some Keratoacanthomas

Cited by 25 publications

References 33 publications

Overexpression of p2l^Waf1/Cip1immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis

Overexpression of p2l^Waf1/Cip1immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis

Keratoacanthoma: A Clinico-Pathologic Enigma

Squamous cell carcinoma arising in a psoriatic nail bed: case report with discussion of diagnostic difficulties and therapeutic options

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p53 Oncoprotein Expression and Gene Mutations in Some Keratoacanthomas

Cited by 25 publications

References 33 publications

Overexpression of p2lWaf1/Cip1immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis

Overexpression of p2lWaf1/Cip1immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis

Keratoacanthoma: A Clinico-Pathologic Enigma

Squamous cell carcinoma arising in a psoriatic nail bed: case report with discussion of diagnostic difficulties and therapeutic options

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Product

Resources

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Overexpression of p2l^Waf1/Cip1immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis

Overexpression of p2l^Waf1/Cip1immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis