2013
DOI: 10.1089/scd.2012.0370
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p53 Regulates Neural Stem Cell Proliferation and Differentiation via BMP-Smad1 Signaling and Id1

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Cited by 58 publications
(39 citation statements)
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References 62 publications
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“…Tedeschi and Di Giovanni [] emphasized the important role of p53 calling it “p53: a decision‐maker in neural progenitor cells” as p53 plays a key role in NCPs differentiation. Moreover, it was demonstred that p53 deficiency leads to increased neurogenesis in vivo [Liu et al, ]. Our results indeed in agreement with these findings, confirmed that simultaneously a downregulation of TP53, observed in hGMSCs after 4 days of treatment with CBD, an increase in the expression level of NEFM and CHRM2, useful as markers for differentiating neurons was found.…”
Section: Discussionsupporting
confidence: 92%
“…Tedeschi and Di Giovanni [] emphasized the important role of p53 calling it “p53: a decision‐maker in neural progenitor cells” as p53 plays a key role in NCPs differentiation. Moreover, it was demonstred that p53 deficiency leads to increased neurogenesis in vivo [Liu et al, ]. Our results indeed in agreement with these findings, confirmed that simultaneously a downregulation of TP53, observed in hGMSCs after 4 days of treatment with CBD, an increase in the expression level of NEFM and CHRM2, useful as markers for differentiating neurons was found.…”
Section: Discussionsupporting
confidence: 92%
“…These data indicate that Id-and Twist-family proteins may govern the senescence process of hUCB-MSCs. In agreement, data from previous reports showed that Id1 and Twist1 serve inhibitory functions during senescence in melanoma cells or MSCs by regulating key cell-cycle regulators, such as p53 and p16 [57][58][59][60].…”
Section: Discussionsupporting
confidence: 90%
“…Our findings show that loss of p53 in human NES cells leads to centrosome amplification resulting in defective mitosis and chromosomal instability, confirming p53 as a key regulator of genomic integrity. p53 has previously been described to regulate stem cell proliferation, and loss of p53 results in enhanced proliferation of mouse neural stem cells in neurosphere assays [39][40][41] . Interestingly, in contrast to findings in mouse neural stem cells, we show that loss of p53 in otherwise healthy human neural stem cells resulted in slower proliferation.…”
Section: Discussionmentioning
confidence: 97%