p53 tumor suppressor and iron homeostasis

Zhang, Jin; Chen, Xinbin

doi:10.1111/febs.14638

Cited by 43 publications

(40 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Iron is required for numerous critical processes such as DNA synthesis, heme synthesis, and iron-sulfur cluster synthesis [129, 130]. It also plays an important role in the active sites of various enzymes which are involved in the formation such as LOX, xanthine oxidase, NADPH oxidases, and mitochondrial complex I and III [131–133].…”

Section: Roles Of Lipid Peroxidation In Different Cell Deathmentioning

confidence: 99%

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Zhang

Gómez

et al. 2019

Oxidative Medicine and Cellular Longevity

1,388

753

View full text Add to dashboard Cite

Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates lipid peroxidation chain reactions, and subsequently induces different types of cell death. A highly evolved sophisticated antioxidant system exists that acts to protect the cells from oxidative damage. In this review, we discussed how ROS propagate lipid peroxidation chain reactions and how the products of lipid peroxidation initiate apoptosis and autophagy in current models. We also discussed the mechanism of lipid peroxidation during ferroptosis, and we summarized lipid peroxidation in pathological conditions of critical illness. We aim to bring a more global and integrative sight to know how different ROS-induced lipid peroxidation occurs among apoptosis, autophagy, and ferroptosis.

show abstract

Section: Roles Of Lipid Peroxidation In Different Cell Deathmentioning

confidence: 99%

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Zhang

Gómez

et al. 2019

Oxidative Medicine and Cellular Longevity

1,388

753

View full text Add to dashboard Cite

show abstract

“…In contrast to other tissues or organs, such as the liver, which is the main organ for iron storage in vivo, there has been no evidence of iron deposition in normal cervical tissues and cervical lesions thus far. 23,24 Therefore, we infer that R2* has good prospects for the hypoxic detection of cervical cancer. In this study, we found that HIF-1α expression had a moderate degree of correlation with R2*, which is in line with previous research.…”

Section: Discussionmentioning

confidence: 86%

“…Usually, iron, hemosiderin, and other paramagnetic substances can affect the value of R2*. In contrast to other tissues or organs, such as the liver, which is the main organ for iron storage in vivo, there has been no evidence of iron deposition in normal cervical tissues and cervical lesions thus far . Therefore, we infer that R2* has good prospects for the hypoxic detection of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Correlation between tumor glucose metabolism and multiparametric functional MRI (IVIM and R2*) metrics in cervical carcinoma: Evidence from integrated ¹⁸F‐FDG PET/MR

Li‐Ou

Sun

Xiao‐Xi

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background Multiparameter, multimodality 18F‐FDG PET/MRI holds great potential for the diagnosis of cervical cancer based on the correlation between tumor glucose metabolism and imaging parameters. Purpose To characterize the heterogeneity of tumor glucose metabolism by evaluating the correlation between 18F‐FDG uptake parameters and multiparametric functional MRI metrics in cervical carcinoma. Study Type Retrospective. Population Fifty‐four patients with cervical carcinoma. Field Strength/Sequence Hybrid PET/MR (3T), multi‐b DWI, and R2* mapping. Assessment The maximum and mean standardized uptake values (SUVmax and SUVmean, respectively) from PET and functional MRI metrics (D, D*, f, and R2*) were obtained. Cervical carcinoma tissues also underwent HIF‐1α, VEGF, and GLUT‐1 immunohistochemical staining. Statistical Tests Single‐factor Spearman rank and Pearson correlation analysis and multiple linear regression (MLR) analysis were applied. Results R2*, D, and f have different degrees of correlation (moderate, weak, moderately strong correlation, respectively) with SUVmax and SUVmean (r = 0.530 and 0.527, and P < 0.001 for R2*; r = –0.292 and –0.291, and P < 0.05 for D; r = 0.539 and 0.520, and P < 0.001 for f, respectively). Immunohistochemical staining showed that HIF‐1α expression has a moderate degree of correlation with R2* (r = 0.491; P < 0.001); GLUT‐1 expression was significantly correlated with SUVmax and SUVmean (r = 0.633 and 0.622; P < 0.001), and VEGF expression had a moderately strong correlation with f (r = 0.457; P = 0.001). If SUVmax is the dependent variable, MLR yields an R‐squared value after adjustment (adjusted R‐squared) = 0.358, and F = 10.833 (P < 0.001), and the fitting linear equation is Y (SUVmax) = 9.184 + 0.161X1 (R2*)+50.343X2 (f)‐4.780 (D). Otherwise, MLR yields the adjusted R‐squared = 0.342, and F = 10.187 (P < 0.001), and the linear regression equation is Y (SUVmean) = 5.925 + 0.102X1 (R2*)+28.029X2 (f)‐2.907X3 (D). Data Conclusion The functional MRI sequence parameters R2*, f, and D can provide information on the hypoxic condition, blood perfusion, and molecular diffusion of the tumor. 18F‐FDG PET/MR multi‐imaging technique can be adopted to evaluate the heterogeneity of glucose metabolism in cervical carcinoma. Level of Evidence: 3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;49:1704–1712.

show abstract

“…The impact of iron on cell cycle progression extends beyond RNR as cyclinD/cyclin-dependent kinase 4 (CDK4) are degraded and protein levels are reduced by iron depletion [68,69]. Iron depletion has also been shown to increase both p53 and p21 expression, leading to increased CDK4 inhibition and cell cycle arrest [70,71]. Conversely, iron overload increases cyclin D1 expression and cell proliferation in mouse hepatocytes [1].…”

Section: Iron and Cancermentioning

confidence: 99%

Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism

Petronek

Spitz

Buettner

et al. 2019

Cancers

View full text Add to dashboard Cite

Iron (Fe) is an essential element that plays a fundamental role in a wide range of cellular functions, including cellular proliferation, DNA synthesis, as well as DNA damage and repair. Because of these connections, iron has been strongly implicated in cancer development. Cancer cells frequently have changes in the expression of iron regulatory proteins. For example, cancer cells frequently upregulate transferrin (increasing uptake of iron) and down regulate ferroportin (decreasing efflux of intracellular iron). These changes increase the steady-state level of intracellular redox active iron, known as the labile iron pool (LIP). The LIP typically contains approximately 2% intracellular iron, which primarily exists as ferrous iron (Fe2+). The LIP can readily contribute to oxidative distress within the cell through Fe2+-dioxygen and Fenton chemistries, generating the highly reactive hydroxyl radical (HO•). Due to the reactive nature of the LIP, it can contribute to increased DNA damage. Mitochondrial dysfunction in cancer cells results in increased steady-state levels of hydrogen peroxide and superoxide along with other downstream reactive oxygen species. The increased presence of H2O2 and O2•− can increase the LIP, contributing to increased mitochondrial uptake of iron as well as genetic instability. Thus, iron metabolism and labile iron pools may play a central role connecting the genetic mutational theories of cancer to the metabolic theories of cancer.

show abstract

p53 tumor suppressor and iron homeostasis

Cited by 43 publications

References 116 publications

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Correlation between tumor glucose metabolism and multiparametric functional MRI (IVIM and R2*) metrics in cervical carcinoma: Evidence from integrated ¹⁸F‐FDG PET/MR

Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism

Contact Info

Product

Resources

About

p53 tumor suppressor and iron homeostasis

Cited by 43 publications

References 116 publications

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Correlation between tumor glucose metabolism and multiparametric functional MRI (IVIM and R2*) metrics in cervical carcinoma: Evidence from integrated 18F‐FDG PET/MR

Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism

Contact Info

Product

Resources

About

Correlation between tumor glucose metabolism and multiparametric functional MRI (IVIM and R2*) metrics in cervical carcinoma: Evidence from integrated ¹⁸F‐FDG PET/MR