P5310Association of n-3 polyunsaturated fatty acids with high-density lipoprotein particle size: a pilot cross-sectional study

Abstract

Lipids, obesity and metabolic syndrome 1117LDL cholesterol level >115 mg/dl, 85.6% had LDL-C >100 mg/dl, and 96.7% had LDL-C >70 mg/dl. HDL cholesterol <40 mg/dl in men and <45 mg/dl in women was present in 84.4% of cases. Triglycerides >150 mg/dl were found in 28.9% of cases. There were 121 (84.0%) patients with BMI ≥25 kg/m 2 -which meets the criteria for overweight. While in the whole study group we could identify 64 (46.5%) obese patients (with BMI ≥30 kg/m 2 ). Waist circumference >94 cm in men and >80 cm in women was found in 106 (73.6%) of patients. Conclusions: Dyslipidemia is highly prevalent in professional drivers. Obesity is one of the major contributors to the cardiovascular risk, and dyslipidemia this along with other risk factors highly prevalent in this subgroup accounts for poorer prognosis. The lipoprotein a levels have been documented to be associated with aortic valve calcification (AVC) which is an active atherosclerotic process. In this study we evaluated the association between AVC and Lipoprotein a [Lp(a)] in patients with familial hypercholesterolemia (FH). Also, the association between Lp(a) and arcus aorta calcification (AAC), coroner artery calcium score (CACS) and aortic elastic features. P5309 | BEDSIDE Methods:The study population consisted of 117 patients (55±13 years of age) who were followed at a University Hospital lipid outpatient clinic for FH and had been evaluated for CACS. CACS imaging was re-evaluated for AVC and AAC by cardiac computed tomography and aortic arch elasticity was evaluated with transthoracic echocardiography. Aortic elastic properties were measured by echocardiography included elastic modulus, aortic stiffnes index, and aortic distensibility. Patients were divided into two groups as Lp(a) levels less than 30mg/dl and higher and equal to 30mg/dl. Results: There was a moderate correlation between AVC and serum Lp(a) (p<0.001 rho=0.43). AAC and CACS had a low correlation with serum Lp(a) levels (p:0,045 rho:0.192 and p:0.01 rho:0.24, respectively). Also we have found that high Lp(a) levels were associated with deteriorated elastic features of arcus aorta. When divided subjects according to Lp(a) levels (less than 30mg/dl and higher and equal to 30mg/dl), patients with high serum Lp(a) had higher AVC, AAC and CACS, more deterioration of the elastic features, which was statistically significant. Conclusions: Lp(a) levels higher or equal to 30mg/dl increases the risk of AVC, AAV and CACS, adversely effects aortic elastic features in patents with FH. P5310 | BEDSIDEAssociation of n-3 polyunsaturated fatty acids with high-density lipoprotein particle size: a pilot cross-sectional study S. Tani, A. Atsumi, R. Matsuo, T. Ashida, A. Hirayama. Nihon University School of Medicine, Tokyo, Japan Background: Decreased high-density lipoprotein cholesterol (HDL-C)/apolipoprotein (apo) A-1ratio, as estimated HDL-particle size may be associated with anti-atherosclerotic effect. That is, cholesterol poor, apo A-I-rich HDL particles would be most likely to favourably reduce risk...