P535 Efficacy of oral supplementation in B12 deficiency in Crohn's disease

Mir, Adil S.; Gracia, Marta; García, ME Cárdaba; Lué, Alberto; Muñoz, Fernándo; García, Sergio Machín; Vicente, Raquel; Gomollón, Fernando

doi:10.1016/s1873-9946(13)60556-5

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“…We want to note that, in 2013, we had presented the preliminary data for our study in the annual congress of Spanish Gastroenterology Association and also in Congress of European Crohn’s and Colitis Organization. Therefore, we believe that our study was the first in evaluating oral B12 therapy in Crohn’s disease patients [21,22]. …”

Section: Discussionmentioning

confidence: 99%

Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn’s Disease

et al. 2017

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Cobalamin deficiency is common in patients with Crohn’s disease (CD). Intramuscular cobalamin continues to be the standard therapy for the deficiency and maintenance treatment in these patients, although oral route has been demonstrated to be effective in other pathologies with impaired absorption. Our aims were to evaluate the efficacy of oral therapy in the treatment of cobalamin deficiency and in long-term maintenance in patients with Crohn’s disease. We performed a multicenter retrospective cohort study that included 94 patients with Crohn’s disease and cobalamin deficiency. Seventy-six patients had B12 deficiency and 94.7% of them normalized their cobalamin levels with oral treatment. The most used dose was 1 mg/day, but there were no significant differences in treatment effectiveness depending on the dose used (≥1 mg/24 h vs. <1 mg/24 h). Eighty-two patients had previous documented B12 deficiency and were treated with oral B12 to maintain their correct cobalamin levels. After a mean follow-up of 3 years, the oral route was effective as maintenance treatment in 81.7% of patients. A lack of treatment adherence was admitted by 46.6% of patients in who the oral route failed. In conclusion, our study shows that oral cyanocobalamin provides effective acute and maintenance treatment for vitamin B12 deficiency caused by CD with or without ileum resection.

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Section: Discussionmentioning

confidence: 99%