P5664Heart failure epidemiology and demographics of multi-cultural population in Malang-Indonesia: data from heart failure registry 2017 in Malang city, Indonesia

Sargowo, Djanggan; Utomo, Yoseph Budi; Rubiyaktho, D; Saragih, Erita; Hendrawati, H; Haspito, M T; Pratama, Aditya Reza; Irawan, Dedy; Nugroho, Faris Wahyu; Adrian, Liemena Harold; Arifin, Yusuf; Kamila, Putri Annisa; Rohman, S

doi:10.1093/eurheartj/ehy566.p5664

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“…Chronic complications of diabetes mellitus essentially occur in all blood vessels throughout the body (diabetic angiopathy). Endothelial dysfunction is an early event that facilitates the occurrence of atherosclerosis which leads the occurence of macroangiopathic complication and microangiopathic diabetes (6).…”

Section: Introductionmentioning

confidence: 99%

Does Chitosan Improve the Lumen of the Heart Arteries in Diabetes Mellitus?

2020

IJITEE

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 Abstract: Diabetes mellitus is known as a metabolic disease characterized by hyperglycemia caused by impaired insulin secretion, insulin action, or both and impaired metabolism of carbohydrates, fats and proteins. Diabetic angiopathy is a chronic complication of diabetes mellitus occurs in essential blood vessels throughout the body, started by endothelial dysfunction of vascular endothelial. Chitosan increases cardiac performance due to amino polysaccharide molecules. This study aims to determine the use of chitosan as adjunctive therapy for diabetes mellitus by looking at the arterial lumen of the heart arteries . Histopathological changes were observed by seeing the blood that filled the lumen of the heart arteries. Sixteen white rats divided into two groups: group 1 as treatment groups were injected by streptozotocin and group 2 as a treatment group was injected streptozotocin and giving chitosan. Data collection of coronary arteries was performed with a score of 3 >75 %, between 25%-75% given two scores, and < 25% were given rating 1. The results of paired t-test can be significant value between the observation of the blood that filled the lumen of the blood vessel of the heart (p:<0,005) indicating there is a significant difference between diabetic rats with streptozotocin that given chitosan compare with diabetic rats were not given chitosan. It can be concluded that chitosan as adjunctive therapy for diabetes mellitus can improve the lumen of the heart arteries.

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Section: Introductionmentioning

confidence: 99%

Does Chitosan Improve the Lumen of the Heart Arteries in Diabetes Mellitus?

2020

IJITEE

View full text Add to dashboard Cite

show abstract

P5664Heart failure epidemiology and demographics of multi-cultural population in Malang-Indonesia: data from heart failure registry 2017 in Malang city, Indonesia

Cited by 1 publication

References 0 publications

Does Chitosan Improve the Lumen of the Heart Arteries in Diabetes Mellitus?

Does Chitosan Improve the Lumen of the Heart Arteries in Diabetes Mellitus?

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