P57.03 Cellular Engagement and Interaction in the Tumor Microenvironment (TME) Predicts Response to ICI in Metastatic NSCLC

Qin, Ailin; Lima, F.; Bell, Sandra; Kalemkerian, Gregory P.; Schneider, B.; Ramnath, N.; Lew, M.; Rao, Auk

doi:10.1016/j.jtho.2021.08.575

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Host-related Biomarkers1

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2022

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“…A TMB 90th percentile was found to be correlated with longer PFS/OS to ICI among NSCLC with PD-L1 levels 50% and 1–49%, and longer PFS among those with PD-L1 < 1% [ 109 ]. Furthermore, the combination of CTL engagement with tumor cell and helper T lymphocytes along with increased expression of PD-L1, which represents enhanced endogenous immune reactivity, more accurately differentiates nonresponders to ICI compared to tumor cell PD-L1 alone and captures the importance of cellular interactions in the TME [ 110 ].…”

Section: Host-related Biomarkersmentioning

confidence: 99%

The key to immunotherapy: how to choose better therapeutic biomarkers for patients with non-small cell lung cancer

Pan

Zeng

et al. 2022

Biomark Res

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Immunotherapy has become the standard of care for non-small cell lung cancer (NSCLC), either in combination or monotherapy. However, there are still some patients who cannot benefit from it. Immunization strategies for NSCLC are based on the expression of PD-L1 on tumor cells and TMB, and although these indicators have a certain predictive effect, their predictive performance is not good. Therefore, clinicians must make adjustments to recognize markers. This is a review article that summarized immunotherapeutic biomarkers according to the “seed-soil-environment”, generalizes primary resistance to immunotherapy, and summarizes the integration of markers.

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Section: Host-related Biomarkersmentioning

confidence: 99%