P586An unusual phenocopy of hypertrophic cardiomyopathy: a case report

Moscatelli, Sara; Nardi, Barbara; Indolfi, Eleonora; Fazzari, Fabio; Montini, Orsola; Coppini, L; Monti, Lorenzo

doi:10.1093/ehjci/jez108.022

Cited by 2 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…Previously, some case reports also demonstrated AMI in HCM with a normal coronary artery or diminutive coronary artery [ 5 – 7 ]. However, MINOCA in HCM is rare and requires further study to uncover the underlying mechanism [ 7 ]. The most likely reason is that ischemia results from an imbalanced oxygen supply and demand at the microvascular level without acute epicardial obstruction [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…MINOCA in patients with hypertrophic cardiomyopathy (HCM) is rare [ 5 – 7 ]. The underlying mechanisms include small-vessel disease with decreased vasodilator capacity, septal perforator artery compression, myocardial bridging, obstruction to left ventricular outflow, inadequate capillary density in relation to the increased myocardial mass, and coronary artery spasm [ 8 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hypertrophic obstructive cardiomyopathy complicated with acute myocardial infarction and diffuse fibrosis: surgery or not?

Wang

Zhao

Zhai

et al. 2022

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Hypertrophic cardiomyopathy with extreme hypertrophy, biventricular obstruction and diffuse myocardial fibrosis complicated by myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) is a rare phenotype. Evidence and guideline recommendations are still lacking for a treatment strategy. Case presentation Emergency coronary angiography was performed in a 38-year-old man with a 2-year history of nonobstructive hypertrophic cardiomyopathy (HCM) presenting with acute myocardial infarction. The coronary angiogram yielded no stenotic lesions but showed a diffusely dilated left descending artery with slow blood flow. All evidence from biomarker analysis, electrocardiography, echocardiography, and imaging supported the diagnosis of acute myocardial infarction in the left ventricular anterior wall. The echocardiogram demonstrated severe interventricular and apical hypertrophy, severe left ventricular outflow tract obstruction and mild right ventricular outflow tract obstruction. Cardiac magnetic resonance imaging showed a concentric morphological subtype of HCM with diffuse late gadolinium enhancement in the left ventricle. Extended septal myectomy was performed 1 month later, and the patient recovered well. Conclusions Hypertrophic obstructive cardiomyopathy with acute myocardial infarction is an indication for coronary angiography. Septal reduction surgery could be performed cautiously in HCM patients with extreme hypertrophy, biventricular obstruction and diffuse myocardial fibrosis complicated by MINOCA to improve the patient’s symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hypertrophic obstructive cardiomyopathy complicated with acute myocardial infarction and diffuse fibrosis: surgery or not?

Wang

Zhao

Zhai

et al. 2022

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Parametric sequences are of paramount interest and are still underutilized in the setting of oncologic phenocopies of HCM: typically, HCM shows increased native T1 and ECV values. In the case of cardiac tumors, ECV calculation often show normal/reduced values (of 25% or less) since the hypertrophic myocardium is characterized by tumor hypercellularity rather than extracellular volume expansion due to fiber disarray [ 52 ].…”

Section: Imaging Of Tumoral Phenocopiesmentioning

confidence: 99%

Tumoral Phenocopies of Hypertrophic Cardiomyopathy: The Role of Cardiac Magnetic Resonance

Francone

Monti

2021

JCM

View full text Add to dashboard Cite

Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease that presents with cardiac hypertrophy. HCM phenocopies are clinical conditions that are phenotypically undistinguishable from HCM, but with a different underlying etiology. Cardiac tumors are rare entities that can sometimes mimic HCM in their echocardiographic appearance, thus representing an example of HCM phenocopy. At present, only case reports of tumoral HCM phenocopies can be found in literature. In this systematic review, we analyzed all the published cases in which a cardiac tumor mimicked HCM to the point of misleading the diagnosis, providing a structured overview of the currently available evidence on this topic.

show abstract

P586An unusual phenocopy of hypertrophic cardiomyopathy: a case report

Cited by 2 publications

References 0 publications

Hypertrophic obstructive cardiomyopathy complicated with acute myocardial infarction and diffuse fibrosis: surgery or not?

Hypertrophic obstructive cardiomyopathy complicated with acute myocardial infarction and diffuse fibrosis: surgery or not?

Tumoral Phenocopies of Hypertrophic Cardiomyopathy: The Role of Cardiac Magnetic Resonance

Contact Info

Product

Resources

About