2013
DOI: 10.1016/s1873-9946(13)60630-3
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P609 5-Aminosalicylate (5-ASA) induced nephrotoxicity in inflammatory bowel disease

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“…Although 5‐ASAs are generally perceived as a safe therapeutic class, infrequent but serious adverse events such as nephrotoxicity can occur . Previous studies on nephrotoxicity are limited to case series studies, and the extent and generalisability of 5‐ASA nephrotoxicity is still debated . A UK‐based retrospective cohort study concluded that 5‐ASA users were at increased risk of renal disease, but there were limitations in the approach of this study including that identified cases were low (n = 130), a mixed population of UC/CD and rheumatoid arthritis patients were included, and the study period evaluated was only current to 2001 .…”
Section: Introductionmentioning
confidence: 98%
“…Although 5‐ASAs are generally perceived as a safe therapeutic class, infrequent but serious adverse events such as nephrotoxicity can occur . Previous studies on nephrotoxicity are limited to case series studies, and the extent and generalisability of 5‐ASA nephrotoxicity is still debated . A UK‐based retrospective cohort study concluded that 5‐ASA users were at increased risk of renal disease, but there were limitations in the approach of this study including that identified cases were low (n = 130), a mixed population of UC/CD and rheumatoid arthritis patients were included, and the study period evaluated was only current to 2001 .…”
Section: Introductionmentioning
confidence: 98%
“…Currently, an international study is being undertaken to see whether the development of interstitial nephritis can be predicted by genome-wide association studies29 based on the observation that patients developing jaundice with flucloxacillin were significantly more likely to develop it with the HLA-B*5701 genotype 23…”
Section: Discussionmentioning
confidence: 99%