p63 regulates <i>Satb1</i> to control tissue-specific chromatin remodeling during development of the epidermis

Fessing, Michael Y.; Mardaryev, Andrei N.; Gdula, Michal R.; Sharov, Andrey A.; Sharova, Tatyana; Rapisarda, Valentina; Гордон, Константин; Smorodchenko, Anna; Poterlowicz, Krzysztof; Ferone, Giustina; Kohwi, Yoshinori; Missero, Caterina; Kohwi‐Shigematsu, Terumi; Botchkarev, Vladimir A.

doi:10.1083/jcb.201101148

Cited by 158 publications

(209 citation statements)

References 68 publications

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“…Brg1 regulates relocation of the EDC away from the nuclear periphery into the nuclear interior and propinquity with nuclear speckles. This is followed by Satb1-regulated arrangement of chromatin conformation within the central domain of the locus, which contains a large number of genes activated during terminal keratinocyte differentiation (Fessing et al 2011;Mardaryev et al 2014). In turn, Lsh regulates chromatin remodeling and mediates DNp63-dependent proliferation and survival of Keratin 15-positive stem cells in the skin (Keyes et al 2011).…”

Section: Va Botchkarev and Er Floresmentioning

confidence: 99%

“…For instance, p63 directly regulates expression of several genes encoding the genome organizer and AT-rich-binding protein Satb1, as well as ATP-dependent chromatin remodelers Lsh and Brg1 in epidermal keratinocytes (Fessing et al 2011;Keyes et al 2011;Mardaryev et al 2014). Both Brg1 and Satb1 play important roles in mediating a p63-regulated program of higherorder chromatin remodeling within the epidermal differentiation complex (EDC) locus.…”

Section: Va Botchkarev and Er Floresmentioning

confidence: 99%

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p53/p63/p73 in the Epidermis in Health and Disease

Botchkarev

Flores

2014

Cold Spring Harbor Perspectives in Medicine

101

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Although p53 has long been known as the "guardian of the genome" with a role in tumor suppression in many tissues, the discovery of two p53 ancestral genes, p63 and p73, more than a decade ago has triggered a considerable amount of research into the role of these genes in skin development and diseases. In this review, we primarily focus on mechanisms of action of p53 and p63, which are the best-studied p53 family members in the skin. The existence of multiple isoforms and their roles as transcriptional activators and repressors are key to their function in multiple biological processes including the control of skin morphogenesis, regeneration, tumorigenesis, and response to chemotherapy. Last, we provide directions for further research on this family of genes in skin biology and pathology.

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Section: Va Botchkarev and Er Floresmentioning

confidence: 99%

Section: Va Botchkarev and Er Floresmentioning

confidence: 99%

p53/p63/p73 in the Epidermis in Health and Disease

Botchkarev

Flores

2014

Cold Spring Harbor Perspectives in Medicine

101

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“…In intact skin, inactivation of DNMT1, the histone methyltransferase Setd8, HDAC1/2, Polycomb components Ezh1/2, and genome organizer Special AT-rich sequence binding protein 1 (SATB1) results in epidermal hypoplasia and suppression of proliferation-associated genes. 29,36,42,48,58 In contrast, overexpression of Cbx4 and Chd4 impairs epidermal proliferation. 47,53 But what effect do epigenetic regulators have on proliferation and differentiation during skin repair?…”

Section: Dynamic Expression Patterns Of Epigenetic Regulators During mentioning

confidence: 99%

“…13 In keratinocytes, AT-rich binding protein Satb1 regulates conformation of the central domain of the EDC locus containing genes activated during terminal keratinocyte differentiation. 58 Ablation of Satb1 results in alterations of higher-order chromatin folding at and elongation of this domain, accompanied by marked alterations of gene expression and epidermal morphology. 58 This suggests that proper chromatin folding at multigene tissuespecific loci is indeed important for maintenance of the proper balance of gene transcription in keratinocytes and outcomes of the transcription programs.…”

Section: Covalent Histone Modificationsmentioning

confidence: 99%

The Epigenetic Regulation of Wound Healing

Lewis

Mardaryev

Sharov

et al. 2014

Advances in Wound Care

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“…SATB1 is primarily expressed in thymocytes, and also the expression of SATB1 in the basal layer of the epidermis is regulated by p63 (5,6). SATB1 can regulate gene expression by folding chromatin into loop domains and tethering DNA domains to the SATB1 network structure (7,8).…”

Section: Introductionmentioning

confidence: 99%

High expression of special AT‑rich sequence binding protein‑1 predicts esophageal squamous cell carcinoma relapse and poor prognosis

et al. 2017

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Abstract. Previous studies of the roles of special AT-rich sequence binding protein-1 (SATB1) in the development and progression of cancer have suggested that SATB1 promotes cancer cell metastasis. The aim of the present study is to evaluate the role of SATB1 in the progression and prognosis of esophageal squamous cell carcinoma (ESCC). ESCC tissues were collected from 102 patients and SATB1 mRNA expression was measured by reverse transcription-quantitative polymerase chain reaction. The association between expression of SATB1 mRNA with clinicopathological features and prognosis was assessed, and the prognosis of ESCC was evaluated using Kaplan-Meier survival curves. In the 102 ESCC tissues, SATB1 mRNA expression correlated with the clinical tumor node metastasis stage (P<0.05), but not with any other clinicopathological features (including age, gender, tumor differentiation grade, adjuvant radio/chemotherapy, or the consumption of alcohol and use of cigarettes) (P>0.05). The disease-free survival (DFS) and overall survival (OS) of patients with high SATB1 expression was decreased compared with those with low SATB1 expression. The present study indicated that SATB1 mRNA expression was associated with the postoperative recurrent and poor prognosis in ESCC. SATB1 may be a novel marker for predicting the recurrent and worse prognosis of ESCC. IntroductionEsophageal cancer cases are distributed worldwide; its mortality rate ranks sixth among all types of cancer and it is the fourth most commonly occurring cancer in China (1,2). China is among the highest risk areas of esophageal cancer, where ~90% of cases are squamous cell carcinoma (SCC) (3). The 5-year survival rate and quality of life remain low (3). However, the molecular mechanisms underlying the initiation and progression of esophageal SCC (ESCC) remain unclear.Special AT-rich sequence binding protein-1 (SATB1), a tissue-specific nuclear matrix binding protein, was identified in 1992 (4). SATB1 is primarily expressed in thymocytes, and also the expression of SATB1 in the basal layer of the epidermis is regulated by p63 (5,6). SATB1 can regulate gene expression by folding chromatin into loop domains and tethering DNA domains to the SATB1 network structure (7,8). Under normal conditions, SATB1 is expressed at low levels in cells and tissues, but is overexpressed in a variety of malignant tumors, including laryngeal squamous cell carcinoma, endometrial cancer, hepatocellular carcinoma, rectal cancer, cutaneous malignant melanoma, gastric cancer, prostate cancer, lung cancer and cutaneous T-cell lymphoma (7,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The expression of SATB1 has been examined in esophageal adenocarcinoma and is an independent prognostic factor (20). In several types of cancer, including laryngeal squamous cell carcinoma, endometrial cancer, hepatocellular cancer and lung cancer, high expression of SATB1 promotes tumor growth and metastasis, and is a negative prognostic factor (7,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). SATB1 can regul...

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p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis

Abstract: Genome organizer Satb1 is regulated by p63 and contributes to epidermal morphogenesis by remodeling chromatin structure and gene expression at the epidermal differentiation complex locus.

Cited by 158 publications

References 68 publications

p53/p63/p73 in the Epidermis in Health and Disease

p53/p63/p73 in the Epidermis in Health and Disease

The Epigenetic Regulation of Wound Healing

High expression of special AT‑rich sequence binding protein‑1 predicts esophageal squamous cell carcinoma relapse and poor prognosis

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