P850 Peripheral and Hepatic Vein Cytokine Levels in Correlation With Non Alcoholic Fatty Liver Disease (Nafld) Metabolic, Histological, and Hemodynamic Features

Vonghia, Luisa; Magrone, T.; Verrijken, An; Pelckmans, P.A.; Michielsen, P.; Gaal, L. Van; Jirillo, Emilio; Francque, S.

doi:10.1016/s0168-8278(14)61011-4

Cited by 2 publications

(5 citation statements)

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“…[24][25][26] The liver has the most significant number of resident macrophages and an increase in pro-inflammatory cytokines (TNF-α, IL-6, CRP) that can be chronically released into the circulation and promote chronic inflammation and thrombotic susceptibility. 27,28 Therefore, it is considered that liver damage and the release of proinflammatory cytokines result in systemic microvascular damage, abnormalities of the coagulation system, altered endothelial dysfunction, and the generation of oxidative stress. It is also suggested that NAFLD and CVD share a common hereditary predisposition.…”

Section: R E L a T I O N S H I P B E T W E E N N A F L D Cardiovascu...mentioning

confidence: 99%

Dislipidemias, hígado graso y enfermedad cardiovascular

Carrillo‐Hidalgo¹,

Fonseca-Coronado²,

Ceballos³

et al. 2022

Cardiovasc Metab Sci

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NAFLD's clinical and economic burden will undoubtedly be overwhelming in the coming decades worldwide. 6 This article will address the association between NAFLD, metabolic syndrome, and cardiovascular disease.NAFLD, a silent pandemic. The global prevalence of NAFLD is 25.4%, being higher in South America (30.45%) and the Middle East (31.79%) and lower in Africa (13.48%). In Asia and the Pacific, NAFLD numbers are also increasing, mainly due to changes in diet and urbanization, and the adoption of the Western lifestyle. 1

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Section: R E L a T I O N S H I P B E T W E E N N A F L D Cardiovascu...mentioning

confidence: 99%

Dislipidemias, hígado graso y enfermedad cardiovascular

Carrillo‐Hidalgo¹,

Fonseca-Coronado²,

Ceballos³

et al. 2022

Cardiovasc Metab Sci

View full text Add to dashboard Cite

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“…Blocking of T-bet by IFN-γ has resulted in attenuation of VAT infl ammation and improved glucose tolerance. Th1 involvement has been detected in DM2 patients [29]. Rau et al [30] have shown an increase of Th1 cells in peripheral blood of NAFLD patients as compared to patients without liver disease [30].…”

Section: T Helper Cells 1 (Th1)mentioning

confidence: 99%

“…Tregs express TF forkhead box P3 (FoxP3) and possess an immune-controlling eff ect. They inhibit the proliferation and function of T eff ector cells and prevent autoreactivity and autoimmune hepatitis [29]. Tregs secrete inhibitory cytokines such as IL-10 and TGF-β [29] and are induced by the secretion of TGF-β, IL-2, and retinoic acid (RA) [24].…”

Section: Regulatory T Cells (Tregs)mentioning

confidence: 99%

“…They inhibit the proliferation and function of T eff ector cells and prevent autoreactivity and autoimmune hepatitis [29]. Tregs secrete inhibitory cytokines such as IL-10 and TGF-β [29] and are induced by the secretion of TGF-β, IL-2, and retinoic acid (RA) [24]. Tregs are divided into two groups: natural Tregs (nTregs) that originate in the thymus, and induced Tregs (iTregs) diff erentiate in the periphery [39].…”

Section: Regulatory T Cells (Tregs)mentioning

confidence: 99%

“…It has been found that Tregs are reduced in the liver as a result of apoptosis [40]. In humans, in obesity studies Treg numbers have been found to be increased in patients with liver steatosis [29,30].…”

Section: Regulatory T Cells (Tregs)mentioning

confidence: 99%

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Dendritic Cells and T Cell Subsets in the Development of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

Gulubova

Hadzhi

Hadzhiilieva

et al. 2021

Acta Medica Bulgarica

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Nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with steatosis, inflammation and fibrosis. Liver dendritic cells (DCs) are usually tolerogenic in the sinusoidal milleu composed of immunosuppressive cytokines. In NAFLD and NASH, DCs become pro-inflammatory and modulate hepatic immune response. Murine liver DCs are three major subtypes: classical (lymphoid) cDC1 or the crosspresenters (CD8α+CD103+), classical (myeloid) cDC2 (CD11b+) and plasmacytoid pDCs (PDCA-1+Siglec-H+) and two additional subtypes or lymphoid + myeloid DCs and NKDCs. Similarly, human liver DCs are three subtypes or CD141+CLEC9A+, CD1c+ (BDCA1+) and pDCs (CD303+BDCA2+). Compared to blood human hepatic DCs are less immature and predominantly induce regulatory T cells (Tregs) and IL-4 secreting T cells (Th2). DCs polarize T cells into different Th types that are in interrelations in NAFLD/NASH. T helper 1 (Th1) (T-bet) cells are associated with adipose tissue inflammation. The differentiation of Th2 (GATA3) cells is induced by IL-4 DCs, increased in NAFLD. Similarly, Th17 cells (RORγt/ RORc) are increased in NAFLD and NASH. Tregs (FoxP3) are increased in the liver in steatosis and Th22 cells (AHR) are elevated in diabetes mellitus 2 (DM2) and adiposity. CD8+ T cells γδT cells and MAIT cells also contribute to liver inflammation.

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P850 Peripheral and Hepatic Vein Cytokine Levels in Correlation With Non Alcoholic Fatty Liver Disease (Nafld) Metabolic, Histological, and Hemodynamic Features

Cited by 2 publications

References 0 publications

Dislipidemias, hígado graso y enfermedad cardiovascular

Dislipidemias, hígado graso y enfermedad cardiovascular

Dendritic Cells and T Cell Subsets in the Development of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

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