P95 Withdrawn P96 Clinically significant drug interactions among HIV-infected patients receiving antiretroviral therapy in outpatient HIV clinic

So-Ngern, Apichot; Manosuthi, W

doi:10.1016/s0924-8579(13)70340-6

International Journal of Antimicrobial Agents

2013

DOI: 10.1016/s0924-8579(13)70340-6

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P95 Withdrawn P96 Clinically significant drug interactions among HIV-infected patients receiving antiretroviral therapy in outpatient HIV clinic

Apichot So-Ngern¹,

W Manosuthi²

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“…[4][5][6][7] Several studies have also confirmed that clinically significant DDIs are common in PLWH, but none have assessed changes in the incidence and severity of DDIs in the setting of ART simplification. [16][17][18] The primary objective of this study was to assess changes in the incidence and severity of DDIs before and after ART simplification in treatment-experienced patients.…”

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The Incidence and Severity of Drug Interactions Before and After Antiretroviral Therapy Simplification in Treatment-Experienced Patients With HIV Infection

2019

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Background: Current guidelines advocate for antiretroviral therapy (ART) simplification in patients on complicated regimens. Simplifying ART improves patient adherence and quality of life, but changes in drug interactions (DIs) are uncertain. Objective: This study assessed changes in DIs following ART simplification in patients with HIV. Methods: This was an observational, retrospective cohort study of patients attending an urban HIV clinic. Patients were included if they had ART simplification (a decreased number of daily tablets) and ≥1 concomitant medication (CM). Total DI scores were generated for each patient pre–ART simplification and post–ART simplification using an online DI database. Each ART-CM pair labeled as “do not co-administer” was given a score of 2, “potential interaction” a score of 1, or “no interaction” a score of 0. Differences in total DI scores following simplification were analyzed with a Wilcoxon Signed-Rank test. Predictors of DI score reductions were examined with linear regression. Results: A total of 99 patients were included. Their median age was 54 years, and 79% were male. The median durations of HIV infection and ART were 16 and 10 years, respectively. Patients were receiving an average of 4.5 CMs. Median interaction scores presimplification and postsimplification were 3 (interquartile range [IQR], 1-6) and 1 (IQR, 0-2) respectively ( P < 0.001). Predictors of score reductions were the patient’s number of CMs, discontinuing a protease inhibitor, and switching to a dolutegravir-based regimen. Conclusion and Relevance: ART simplification decreased the incidence of DIs in this analysis of patients with advanced age who had ART experience and polypharmacy.

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The Incidence and Severity of Drug Interactions Before and After Antiretroviral Therapy Simplification in Treatment-Experienced Patients With HIV Infection

2019

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P95 Withdrawn P96 Clinically significant drug interactions among HIV-infected patients receiving antiretroviral therapy in outpatient HIV clinic

Cited by 1 publication

References 0 publications

The Incidence and Severity of Drug Interactions Before and After Antiretroviral Therapy Simplification in Treatment-Experienced Patients With HIV Infection

The Incidence and Severity of Drug Interactions Before and After Antiretroviral Therapy Simplification in Treatment-Experienced Patients With HIV Infection

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