PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway

Zhu, Changren; Wang, Cuimei; Wang, Xiaodong; Dong, Shuangshuang; Xu, Qing; Zheng, Jun

doi:10.1007/s10616-024-00626-1

Cytotechnology

2024

DOI: 10.1007/s10616-024-00626-1

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PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway

Changren Zhu,

Cuimei Wang,

Xiaodong Wang

et al.

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2024

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Cited by 2 publications

References 32 publications

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Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway

Wu,

Guo,

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway

Wu,

Guo,

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Comprehensive Analysis of Tertiary Lymphoid Structures in Pancreatic Cancer: Molecular Characteristics and Prognostic Implications

Fang,

Huang,

Zhang

et al. 2024

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Purpose: The molecular properties of TLSs in pancreatic cancer are still not well comprehended. This research delved into the molecular properties of intratumoral TLSs in pancreatic cancer through the exploration of multi-omics data. Methods: Seven key genes were identified through Cox regression analysis and random survival forest analysis from a total of 5908 genes related to TLSs. These genes were utilized to construct a prognosis model, which was subsequently validated in two independent cohorts. Additionally, the study investigated the molecular features of different populations of TLSs from multiple perspectives. The model’ s forecasting accuracy was verified by analyzing nomogram and decision curves, taking into account the patients’ clinical traits. Results: The analysis of immune cell infiltration showed a notably greater presence of Macrophage M0 cells in the group at high risk than in the low-risk group. The pathway enrichment analysis demonstrated the activation among common cancer-related pathways, including ECM receptor interaction, pathways in cancer, and focal adhesion, in the high-risk group. Additionally, the methylation study revealed notable disparities in DNA methylation between two TLS groups across four regions: TSS200, 5’ UTR, 1stExon, and Body. A variety of notably distinct sites were linked with PVT1. Furthermore, by constructing a competing endogenous RNA network, several mRNAs and lncRNAs were identified that compete for the binding of hsa-mir-221. Conclusion: Overall, this research sheds light on the molecular properties of TLSs across various pancreatic cancer stages and suggests possible focal points for the treatment of pancreatic cancer.

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PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway

Cited by 2 publications

References 32 publications

Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway

Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway

Comprehensive Analysis of Tertiary Lymphoid Structures in Pancreatic Cancer: Molecular Characteristics and Prognostic Implications

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