For the traditional laboratory manual management, there is a need for laboratory managers. The managers cannot keep abreast of the laboratory conditions, and forget to shut down and close the windows, causing waste of electricity and equipment damage. Based on NB-IoT and artificial intelligence, a laser intelligent management system is developed using technologies such as network communication, intranet, automatic control, artificial intelligence, and software. Through this system, administrators can grasp the situation of the laboratory in real time, realize the intelligent management of the laboratory, improve the scientific management of the laboratory, improve the work efficiency of laboratory technicians, and better play the laboratory as an important platform for scientific research training in colleges and universities. This paper aims to develop an intelligent laboratory management system based on NB-IoT and AI technology. Through this system, the manager can grasp the situation of the laboratory in real time, realize the intelligent management of the laboratory, and better play the role of the laboratory as an important platform for scientific research and talent training.