cardiac pacing, sick sinus syndrome, repetitive nonreentrant VA synchrony, rate-responsive pacing
Case PresentationA 66-year-old man underwent implantation of a model 5826, Zephyr TM XL DR pacemaker (St. Jude Medical, Sylmar, CA, USA) for management of sinus node dysfunction associated with paroxysmal atrial fibrillation (AF). Models 1999 and 2088TC active-fixation leads (St. Jude) were implanted in the right atrial appendage and right ventricular mid septum, respectively. Since the sinus rate was 36 beats per minute (bpm) with frequent sinus arrests and episodes of AF, the pacemaker was programmed in DDIR mode with a backup rate of 60 pulses per minute (ppm), maximum sensor-driven rate limit at 120 ppm, and a 300-ms paced atrioventricular (AV) interval. The postventricular atrial refractory periods (PVARP) and postventricular atrial blanking period were set at 275 and 140 ms, respectively. The rate response was programmed "ON," with an auto (+2) response slope, and reaction and recovery times set to fast and medium, respectively. The rate-responsive AV delay was programmed "OFF," the rate-responsive PVARP "LOW," and shortest PVARP at 170 ms. Far-field R-wave oversensing was prevented by the postventricular atrial blanking period setting. The atrial high-rate episodes (AHRE) function was activated to detect atrial rates >170 bpm. Since the P-wave sensing and atrial capture threshold were 2.4-2.7 mV and 0.75 V/0.4 ms, respectively, the atrial sensitivity and pulse amplitude were set at 0.2 mV and 2.5 V/0.4 ms, respectively. Oral bepridil, 150 mg t.i.d., was administered for the prevention of paroxysmal AF.The intracardiac electrograms (iEGM) of recorded AHRE were reviewed 1 week after pacemaker implantation. The recording in Figure 1 shows that while the patient was climbing up and downstairs the sensor-driven atrial pacing (AP) rate increased to 80 ppm. The ventriculoatrial (VA) interval after ventricular pacing (VP) was 220 ms, and the atrial electrogram induced by VA conduction was sensed within the PVARP. Sensor-driven, rate-adaptive DDIR pacing occurred 200 ms after the retrograde P wave was sensed. However, the atrium was not captured, because of persistent refractoriness. Following this ineffective atrial paced event, VP occurred at the programmed AV interval of 300 ms. This lasted for 1 minute 36 seconds, while the patient continued to climb up and downstairs. Pacemaker interrogation revealed normal pacing and sensing thresholds and lead impedances. What is the mechanism of the noncaptured AP and continuous VP in this patient with sinus node dysfunction?
DiscussionRepetitive, nonreentrant VA synchrony (RNR-VAS) is not a rare phenomenon with dual-chamber pacemakers. 1,2 Most previously described cases of RNRVAS, which accelerate the pacing rate, have been associated with sensor-driven DDDR pacing. 1,2 This form of VA synchrony is associated with programmed long AV intervals and relatively high atrial rates during DDD or DDDR pacing. We have recently reported a case of RNRVAS, recorded as AHRE in the pacemak...