Pacharin: a new dibenzo(2,3-6,7)oxepin derivative from bauhinia racemosa lamk

Anjaneyulu, A. S. R.; Reddy, A. Venugopal; Reddy, D. Srinivasa; Ward, Robert S.; Adhikesavalu, D.; Cameron, T. Stanley

doi:10.1016/s0040-4020(01)98799-x

Cited by 59 publications

(34 citation statements)

References 7 publications

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“…Moreover, the HMBC and NOESY correlations HÀC(7)/C(2) and C(6), HÀC(8)/C(2') and C(6'), and HÀC(7)/HÀC(2') and HÀC(8)/HÀC(6) were observed. These spectra were consistent with those published for (E)-resveratrol [19] 123.2 (CH), 164.5 (C), and 55.6 (Me) as well as HMBC HÀC(6'''')/C(7'''') and Me(8'''')/C(3'''') (see Fig. 1) indicated a vanilloyl moiety in 1.…”

supporting

confidence: 90%

Acylated Stilbene Glucosides and Further Constituents from Acanthopanax brachypus

Zheng

et al. 2009

Helvetica Chimica Acta

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supporting

confidence: 90%

Acylated Stilbene Glucosides and Further Constituents from Acanthopanax brachypus

Zheng

et al. 2009

Helvetica Chimica Acta

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“…A survey of literature revealed the isolation of some phenolics, aliphatic acids, triterpenoids, and amino acids from the heartwood (Anjaneyulu et al, 1984(Anjaneyulu et al, , 1986, stem bark (Prakash et al, 1976), and roots (Prabhakar et al, 1994, Jain et al, 2002. The present research is focused on the isolation of polyphenolics and antifungal, antibacterial and antiviral activities of the diethyl ether and methanolic extracts and the isolated polyphenolics.…”

Section: Introductionmentioning

confidence: 93%

Bioactivities of polyphenolics from the roots of Bauhinia racemosa

et al. 2008

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Various extracts of Bauhinia racemosa Lamk. (roots) and the isolated polyphenolics, viz. 1,7,8,12b-tetrahydro-2,2,4-trimethyl-10-methoxy-2H-benzo [6,7] cyclohepta[1,2,3-de][1]benzopyran-5,9-diol (racemosol) (1), 1,7,8,12b-tetrahydro-2,2,4-trimethyl-2H-benzo[6,7]cyclohepta[1,2,3-de][1]benzopyran-5,10,11-triol (2), and 1,7,8,12b-tetrahydro-2,2,4-trimethyl-2H-benzo[6,7] cyclohepta [1,2,3-de][1]benzopyran-5,9,10-triol (de-O-methyl racemosol) (3) were screened for antibacterial, antifungal, and antiviral activities. The isolated compounds exhibited profound antibacterial and antifungal activities while methanol extract exhibited potential efficacy against Herpes simplex virus.

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“…Beside these compounds, at least five flavonols (kaempferol and quercetin) and two coumarins (scopoletin and scopolin) were also isolated from the leaves of the plant (11). Stilbene (resveratrol) was isolated from the heartwood of B. racemosa (12). Pharmacological studies of the plant have revealed that the ethanol extract of B. racemosa leaves shows analgesic, antipyretic, anti-inflammatory, and antispasmodic activities (13), as well as antimicrobial activity (14).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antimicrobial activities of Bauhinia racemosa L. stem bark

Kumar

Sivakumar²,

Sunderam³

et al. 2005

Braz J Med Biol Res

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The present study was carried out to evaluate the antioxidant and antimicrobial activities of a methanol extract of Bauhinia racemosa (MEBR) (Caesalpiniaceae) stem bark in various systems. 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) radical, superoxide anion radical, nitric oxide radical, and hydroxyl radical scavenging assays were carried out to evaluate the antioxidant potential of the extract. The antioxidant activity of the methanol extract increased in a concentration-dependent manner. About 50, 100, 250, and 500 µg MEBR inhibited the peroxidation of a linoleic acid emulsion by 62.43, 67.21, 71.04, and 76.83%, respectively. Similarly, the effect of MEBR on reducing power increased in a concentration-dependent manner. In DPPH radical scavenging assays the IC 50 value of the extract was 152.29 µg/ ml. MEBR inhibited the nitric oxide radicals generated from sodium nitroprusside with an IC 50 of 78.34 µg/ml, as opposed to 20.4 µg/ml for curcumin. Moreover, MEBR scavenged the superoxide generated by the PMS/NADH-NBT system. MEBR also inhibited the hydroxyl radical generated by Fenton's reaction, with an IC 50 value of more than 1000 µg/ml, as compared to 5 µg/ml for catechin. The amounts of total phenolic compounds were also determined and 64.7 µg pyrocatechol phenol equivalents were detected in MEBR (1 mg). The antimicrobial activities of MEBR were determined by disc diffusion with five Grampositive, four Gram-negative and four fungal species. MEBR showed broad-spectrum antimicrobial activity against all tested microorganisms. The results obtained in the present study indicate that MEBR can be a potential source of natural antioxidant and antimicrobial agents.

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Pacharin: a new dibenzo(2,3-6,7)oxepin derivative from bauhinia racemosa lamk

Cited by 59 publications

References 7 publications

Acylated Stilbene Glucosides and Further Constituents from Acanthopanax brachypus

Acylated Stilbene Glucosides and Further Constituents from Acanthopanax brachypus

Bioactivities of polyphenolics from the roots of Bauhinia racemosa

Antioxidant and antimicrobial activities of Bauhinia racemosa L. stem bark

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