Pachychoroid pigment epitheliopathy in fellow eyes of patients with unilateral central serous chorioretinopathy

Ersöz, Mehmet Giray; Karaçorlu, Murat; Arf, Serra; Hocaoğlu, Mümin; Muslubaş, Işıl Sayman

doi:10.1136/bjophthalmol-2017-310724

Cited by 52 publications

(39 citation statements)

References 26 publications

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“…The female/male ratio of these Turkish patients with CSC was 1/2.7, consistent with our previous study 18. The female/male ratio was significantly higher in chronic cases (1/3.4) than classic cases (1/2.4).…”

Section: Discussionsupporting

confidence: 91%

Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients

et al. 2018

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Section: Discussionsupporting

confidence: 91%

Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients

et al. 2018

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“…Pachychoroid features are sometimes associated with not only retinal diseases [24, 25] but also neuroophthalmological diseases including nonarteritic anterior ischemic optic neuropathy and glaucoma [26, 27]. In unilateral central serous chorioretinopathy, even the fellow eyes have pachychoroid features in 92% of cases [24]. In the present study, some of the patients with amblyopia had a much larger outer choroidal vascular area in both eyes.…”

Section: Discussionmentioning

confidence: 47%

“…Additionally, pachychoroid disorders are receiving a lot of attention in the field of retina research and imply choroidal manifestations, including increased choroidal thickness and dilation of the outer choroidal vessels, and are involved in the underlying pathology [23]. Pachychoroid features are sometimes associated with not only retinal diseases [24, 25] but also neuroophthalmological diseases including nonarteritic anterior ischemic optic neuropathy and glaucoma [26, 27]. In unilateral central serous chorioretinopathy, even the fellow eyes have pachychoroid features in 92% of cases [24].…”

Section: Discussionmentioning

confidence: 99%

Abnormal Outer Choroidal Vasculature in Amblyopia

Terada

Miyata

Muraoka

et al. 2019

Journal of Ophthalmology

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Purpose Several studies have indicated morphological changes in the choroid in amblyopia cases. This study investigates whether choroidal vasculature was different among amblyopic and fellow eyes in unilateral amblyopia patients and healthy eyes, using en face images acquired via swept-source optical coherence tomography (SS-OCT). Design Prospective, observational case-control study. Methods This study included 14 consecutive patients with unilateral amblyopia and 22 age- and axial length-matched healthy eyes. Using SS-OCT, we obtained en face images of choroidal vasculature midway through the subfoveal inner and total choroid, corresponding to the vasculature of the choriocapillaris and Sattler's layer (inner choroid) and Haller's layer (outer choroid), respectively. We analyzed the en face images of the inner and outer choroidal vascular areas in 3 × 3 mm squares adjusted from 6 × 6 mm squares, using Littmann's magnification correction, after binarization of the images as a portion of the whole area. Results The outer choroidal vascular areas were larger in both amblyopic and fellow eyes than in healthy eyes (both P < 0.001), although there were no significant differences in inner (56.35 ± 2.46% and 56.27 ± 3.75%, respectively) or outer (61.49 ± 4.95% and 61.48 ± 3.73%, respectively) choroidal vascular area between amblyopic and fellow eyes (P=0.98 and 0.91, respectively). An outer choroidal vascular area of 59% was set as an appropriate cutoff value for distinguishing patients from controls. Conclusions The outer choroidal vascular area was larger in both amblyopic eyes and fellow eyes compared to healthy eyes. Our findings may help clarify the etiology of amblyopia.

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“…We recruited consecutive patients with PPE (PPE group), patients with pachychoroid eye without changes in the retina (Pachy group), and patients with normal choroid and retina (controls) that visited our hospital between June 2017 and March 2018. Diagnosis of pachychoroid was based on previously established definitions 2,19 , (i.e. subfoveal choroidal thickness >300 μm or an extrafoveal focus that exceeded fovea choroidal thickness by at least 50 μm), and the presence of pachyvessels identified on OCT b-scans and en face images 6 .…”

Section: Methodsmentioning

confidence: 99%

Choriocapillaris Flow Impairments in Association with Pachyvessel in Early Stages of Pachychoroid

Baek

Lee

2019

Sci Rep

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To analyze features of the choriocapillaris in eyes with earlier stages of pachychoroid spectrum, this study included 46 eyes with PPE, 32 age-matched eyes with pachychoroid without epitheliopathy, and 30 normal controls. Macular 3 × 3 mm 2 angiographic images were obtained with swept-source optical coherence tomography. Vascular density and signal void area in the choriocapillaris were analyzed. Topographical correlation of signal voids with the dilated choroidal large vessel (pachyvessel) was assessed. Choriocapillaris vascular density was significantly lower in eyes with PPE compared with controls ( p = 0.003). The number, the total area and the average size of signal voids was the highest in the PPE group followed by the pachychoroid without epitheliopathy and then controls (all p ≤ 0.001). 89.0% signal void area colocalized with pachyvessels. The average size of the signal void was higher if it was colocalized with pachyvessel ( p < 0.001). In conclusion, the area of flow impairment in the choriocapillaris was increased in eyes with pachychoroid and even greater when epitheliopathy was present. Pachyvessel was associated with choriocapillaris flow impairment by location and size.

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Pachychoroid pigment epitheliopathy in fellow eyes of patients with unilateral central serous chorioretinopathy

Abstract: PPE is common in fellow eyes of patients with CSC. There is no difference between PPE and UCP regarding demographic characteristics and medical features.

Cited by 52 publications

References 26 publications

Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients

Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients

Abnormal Outer Choroidal Vasculature in Amblyopia

Choriocapillaris Flow Impairments in Association with Pachyvessel in Early Stages of Pachychoroid

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