Pachymic acid protects against cerebral ischemia/reperfusion injury by the PI3K/Akt signaling pathway

Pang, Yingqiao; Zhu, Shaozhi; Pei, Haitao

doi:10.1007/s11011-020-00540-3

Cited by 33 publications

(17 citation statements)

References 33 publications

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“…The reasons are considered as follows: ①Excessive activation of mTOR can lead to gene expression of cerebral cortical malformation and the epileptic phenotype [24]; ②PI3K/Akt/mTOR signaling pathway participates in cell synthesis and proliferation and promotes the synthesis of microglia [25], thereby aggravating the immune inflammatory response and increasing inflammatory cell exudation.③PI3K/Akt/mTOR signal activates hypoxia-inducible factors and regulates the glucose transporter (GLUT), resulting in excessive activation of neurons [26]. Contrary to the postulated role of the PI3K/Akt/mTOR pathway in epilepsy pathology, there have been reports that this signaling cascade confers protective effects due to reducing neuronal apoptosis and ischemic brain injury [27]. A reason for this may be that mTOR is part of two main signaling complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2).…”

Section: Discussionmentioning

confidence: 99%

A study on the protective mechanism of mTOR inhibitor Everolimus on brain injury after epilepsy

Huang¹,

Hu²,

Zheng³

et al. 2020

Preprint

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Background: Epilepsy is a common acute and severe disease in infants and children. Recurrent seizures or status epilepticus can cause irreversible brain damage. While the PI3K/Akt/mTOR pathway regulates various physiological processes of neurons and glia, it may also lead to abnormal neuronal signal transduction under pathological conditions, including that of epilepsy. Everolimus (Eve) is an mammalian target of repamycin (mTOR) inhibitor that may affect neuronal excitability and have a therapeutic effect on epilepsy. Therefore, this study aimed to investigate the protective effect of Everolimus on post-epileptic brain injury and the regulation mechanism of the PI3K/Akt/mTOR and NF-kB/IL-6 signaling pathway. Intraperitoneal administration of kanic acid (KA) 15mg/kg was used to induce epilepsy in the developing rat and Everolimus (1, 2, 5mg/kg) was injected intraperitoneally 2 hours before KA injection. Cerebral cortex tissue was sampled at 24 hours post-epilepsy.Results: The protein and mRNA levels of PI3K、AKt、mTOR、NF-kB and IL-6 as well as microglia activation significantly increased after KA-induced epilepsy, however these effects were inhibited by Everolimus treatment. Furthermore, pretreatment with Everolimus decreased seizure scores and increased seizure latency. This study demonstrates that mTOR inhibitor.Conclusions: Everolimus can decrease the PI3K/Akt/mTOR and NF-kB/IL-6 signaling pathway, reduce microglia activation, and attenuate seizure susceptibility and intensity, thus having a protective effect on post-epileptic brain damage.

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Section: Discussionmentioning

confidence: 99%

A study on the protective mechanism of mTOR inhibitor Everolimus on brain injury after epilepsy

Huang¹,

Hu²,

Zheng³

et al. 2020

Preprint

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“…Poria also showed effect on tyrosinase activity [99][100][101]. In addition, pachymic acid (1) had protective effects against cerebral ischemia-reperfusion injury and neuronal apoptosis [102]; epidermis extract could be a potential treatment for epilepsy [103]. Poria's aqueous extract, alcohol extract, and polysaccharide showed the protective effects on acute liver injury caused by carbon tetrachloride [104].…”

Section: 9mentioning

confidence: 99%

Phytochemistry and Biological Activities of Poria

Lü

Tian

Zhou

et al. 2021

Journal of Chemistry

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Poria is a common Traditional Chinese Medicine in clinic. In recent years, the chemical and pharmacological studies of Poria have made great progress, triterpenes and polysaccharides have been isolated, and various types of compounds containing lipids, octanoic acids, fatty acids, and trace elements have been found. In this paper, we reviewed the literature, summarized the main compound types, and reviewed in detail their pharmacological effects in antitumor, immunomodulatory, effects on kidney, hepatoprotective activity, effects on blood sugar, antioxidant effects, anti-inflammatory effects, effects on the gut, antidepressant, and so on, and also categorized the compounds with the same or similar pharmacological effects to provide a reference for the in-depth study of the material basis of the pharmacological effect, quality standards, and pharmacological activity of Poria.

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“…It is mainly used to treat edema and oliguria, sputum drinking and dizziness, spleen deficiency, restlessness, convulsions, and insomnia. Clinically, PCW is mainly used for treating renal fibrosis, 65 osteoporosis, 66 malignant tumors, 67 cerebral ischemia/reperfusion injury, 68 depression, 69 fatty liver, 70 diabetes, 71 and AD. 72 PC is abundantly available, and its pharmacological effects are remarkable.…”

Section: Curcumae Radix (Cr)mentioning

confidence: 99%

“…So far, the main chemical components that have been separated from PC include poria glycans, pachymic acid, as well as sterols, choline, adenine, lecithin, and histidine acid. The pharmacological effects of pachymic acid include antitumor activity, 73 improving learning and memory impairment, 74 protecting against cerebral ischemia/reperfusion injury, 68 ameliorating renal failure, 75 improving survival and attenuating acute lung injury, 76 improving sleep, 77 and exerting anti-inflammatory 78…”

Section: Curcumae Radix (Cr)mentioning

confidence: 99%

<p>Research Progress on Classical Traditional Chinese Medicine Jieyu Pills in the Treatment of Depression</p>

Wang¹,

Miao²

2020

NDT

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Pachymic acid protects against cerebral ischemia/reperfusion injury by the PI3K/Akt signaling pathway

Cited by 33 publications

References 33 publications

A study on the protective mechanism of mTOR inhibitor Everolimus on brain injury after epilepsy

A study on the protective mechanism of mTOR inhibitor Everolimus on brain injury after epilepsy

Phytochemistry and Biological Activities of Poria

<p>Research Progress on Classical Traditional Chinese Medicine Jieyu Pills in the Treatment of Depression</p>

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